Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment

Table 3 Pathways enriched for downregulated genes in miR-29a overexpressing hPSCs

Pathway name	Genes	P value
Cell cycle	GINS1; PLK4; TOP2A; GINS2; BLM; CDCA5; PLK1; HJURP; CASC5; ESCO2; CENPA; AURKB; SKA1; CENPE; CENPF; EXO1; E2F1; E2F7^a; NEK2; MYBL2^a; SPDL1	R = 683; G = 21, p value = 2.07E-10
Tp53 pathway	BLM; EXO1; FANCD2; E2F1; SPDL1; E2F7^a; AURKB	R = 259; G = 7; p value = 0.02074
Signaling by Ras mutants	NRAS^a; IQGAP3	R = 54; G = 2; p value=6.41E-04
IGF pathway	NRAS^a; LAMC1^a; IGF1^a; FSTL1^a; PAPPA2	R = 127; G = 5; p value=0.032048
Laminin interactions	ITGA2; ITGA6^a; LAMC1^a	R = 31; G = 3; p value=0.003216579
Collagen binding	RC15; COL5A3^a; ABI3BP; ITGA2; LRRC15	R = 53; G = 5; p value=0.00125
Collagen biosynthesis and metabolic pathway	COL5A3^a; ADAMTS2^a; ITGA2	R = 84; G = 3; p value=0.04578

R = the number of reference genes in the category; G = number of genes in the gene set for each category; ^a miR-29a direct targets

ISSN: 1471-2407