Table 3 Pathways enriched for downregulated genes in miR-29a overexpressing hPSCs

Cell cycle

GINS1; PLK4; TOP2A; GINS2; BLM; CDCA5; PLK1; HJURP; CASC5; ESCO2; CENPA; AURKB; SKA1; CENPE; CENPF; EXO1; E2F1; E2F7^a; NEK2; MYBL2^a; SPDL1

R = 683; G = 21, p value = 2.07E-10

Tp53 pathway

BLM; EXO1; FANCD2; E2F1; SPDL1; E2F7^a; AURKB

R = 259; G = 7; p value = 0.02074

Signaling by Ras mutants

NRAS^a; IQGAP3

R = 54; G = 2; p value=6.41E-04

IGF pathway

NRAS^a; LAMC1^a; IGF1^a; FSTL1^a; PAPPA2

R = 127; G = 5; p value=0.032048

Laminin interactions

ITGA2; ITGA6^a; LAMC1^a

R = 31; G = 3; p value=0.003216579

Collagen binding

RC15; COL5A3^a; ABI3BP; ITGA2; LRRC15

R = 53; G = 5; p value=0.00125

Collagen biosynthesis and metabolic pathway

COL5A3^a; ADAMTS2^a; ITGA2

R = 84; G = 3; p value=0.04578