Skip to main content

Table 2 Most relevant biological processes associated with downregulated genes in miR-29a overexpressing hPSCs

From: Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment

Biological Process

Gene Name

Ratio

p value

Positive regulation of cell proliferation

IGF1a; KIF14; IL1B; ESM 1; BCL2; KIF20B

6/490

0.024382

Cell division

CENPF; SPDL1; KIF14; SKA3; KIFC1; NEK2; SKA1; KIF18B; CENPE; CDCA5; KIF20B

11/346

4.69E-07

Regulation of G2/M transition of mitotic cell cycle

CENPF; KIF14; PLK4; NEK2; PLK1

5/80

3.2E-05

Negative regulator of extrinsic apoptotic pathway

ITGA6a; IGF1a

2/35

0.011085

Cell adhesion

LAMC1a; PCDH9a; PODXL; ITGA2; PCDH1; AJAP1

6/454

0.017486

Cell matrix adhesion

COL5A3a; ITGA6a; ADAMTS12; ITGA2

4/95

0.000932

Focal adhesion assembly

ITGA2; BCL2

2/27

0.006695

Positive regulation of fibroblast proliferation

IGF1a; E2F1

2/49

0.021029

Collagen fibril organization

COL5A3a; ADAMTS2a

2/46

0.018671

Extracellular matrix organization

COL5A3a; LAMC1a; ITGA6a; ITGA2; ABI3BP; PTX3

6/229

0.000624

Cell junction organization

ITGA6a;CLDN1a; LAMC1a; ITGA2

4/37

0.002963

Positive regulation of cell migration

CLDN1a; ITGA6a; IGF1a; PLAU; F2RL1; PODXL; LRRC15; IL1B

8/224

8.23E-06

Positive regulation of inflammatory response

ITGA2; IL1B

2/75

0.046007

Positive regulation of IL-6 secretion

F2RL1; IL1B

2/33

0.009895

  1. a miR-29a direct targets