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Table 2 Comparison of various cytological features which point towards phyllodes tumor versus fibroadenoma, based on univariate generalized estimating equations

From: Fibroadenoma versus phyllodes tumor: a vexing problem revisited!

Cytological feature

Odds Ratio

95% CI of Odds Ratio

pvalue

Epithelial component

 Overall cellularity

   Marked

0.28

0.06–1.24

0.093

   Moderate

0.59

0.16–2.27

0.448

   Milda

0a

 Epithelial clusters per slide

   > 5

0.06

0.01–0.67

0.019

   1–5

0.71

0.01–17.51

0.845

   < 1a

0a

 Epithelial clusters

   Branched

0.75

0.39–1.46

0.401

   Cohesive

1.23

0.42–3.60

0.705

   Opened large folded

3.81

1.86–7.82

<  0.001

   Staghorn

0.66

0.35–1.26

0.208

   Tubular

0.39

0.11–1.43

0.156

   Crowded

0.47

0.09–2.54

0.381

 Degree of dissociation

1.28

0.22–7.37

0.779

 Epithelial atypia

2.84

1.11–7.23

0.029

 Epithelial mitosis

1.87

0.12–29.48

0.655

 Apocrine metaplasia

0.66

0.25–1.70

0.386

 Epithelial giant cells

0.74

0.29–1.85

0.516

Stromal component

 Fragments per slide

   > 5

2.36

0.19–328.86

0.549

   1–5

3.68

0.29–514.29

0.347

   < 1a

0a

 Size of stromal clusters

   Large

1.95

0.52–7.38

0.324

   Intermediate

1.74

0.62–4.89

0.294

   Smalla

0a

 Contours of stromal fragments

   Irregular

3.29

1.03–10.54

0.044

   Frayed

4.85

1.07–21.88

0.040

   Rounda

0a

 Stromal cellularity

   Marked

1.43

0.24–8.46

0.693

   Moderate

2.84

1.09–7.39

0.032

   Milda

0a

 Traversing blood vessels

1.75

0.76–4.02

0.189

 Myxoid fragments

1.29

0.56–2.96

0.551

 Fibro myxoid fragmentsa

0a

 Shape of stromal nuclei

   Spindle

3.35

1.31–8.55

0.011

   Plump

4.67

0.49–44.28

0.180

   Ovala

0a

Background cell population

 Background cellularity

   Marked

0.75

0.19–2.65

0.604

   Moderate

1.10

0.40–3.07

0.851

   Milda

0a

 Shape of background cell nuclei

   Spindle

7.93

3.79–16.58

<  0.001

   Plump

3.50

0.80–15.29

0.096

   Ovala

0a

 Proportion of spindle cells

   > 30%

399.67

22.70–737.93

<  0.001

   10–30%

87.97

10.04–770.56

<  0.001

   < 10%a

0a

 Background cell atypia

5.42

2.19–13.37

<  0.001

 Background cell mitosis

9.93

0.94–105.30

0.057

Other cells

 Cyst macrophages

1.13

0.18–6.91

0.899

 Columnar cellsa

0a

  1. aReference category