Comparative effectiveness trial of transoral head and neck surgery followed by adjuvant radio(chemo)therapy versus primary radiochemotherapy for oropharyngeal cancer (TopROC)

Table 1 chemotherapy protocols

Option	Treatment	Days of treatment	Annotation
1	Cisplatin 100 mg/m² i.v.	Days 1, 22 and 43
2	Cisplatin 30 − 40 mg/m² i.v.	Weekly (days 1, 8, 15, 22, 29 and 36)
3	Mitomycin C 10 mg/m² i.v. 5-FU 600 mg/m²/day i.v.	Days 1, 29 Days 1–5	Only in case of GFR < 60 ml/min
4	Cisplatin 20 mg/m² i.v. 5-FU 600 mg/m²/day i.v.	Days 1–5 and 29–33 Days 1–5 and 29–33

ISSN: 1471-2407