Table 3 Multivariate analysis for overall survival in patients with Waldenström macroglobulinemia
Variable | Number (%) | 2-year HR | 95% CI | P | 5-year HR | 95% CI | P | 10-year HR | 95% CI | P | Total HR | 95% CI | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age (years) | |||||||||||||
20–49 | 26 (6.09) | Reference | Reference | Reference | Reference | ||||||||
50–59 | 63 (14.75) | 2.61 | 0.58–11.78 | 0.21 | 2.43 | 0.70–8.48 | 0.16 | 2.22 | 0.83–5.89 | 0.11 | 2.30 | 0.86–6.12 | 0.10 |
60–69 | 121 (28.34) | 4.99 | 1.20–20.67 | 0.03 | 5.28 | 1.65–16.93 | 0.01 | 4.06 | 1.62–10.13 | 0.00 | 4.34 | 1.74–10.84 | < 0.01 |
70–79 | 165 (38.64) | 5.32 | 1.29–21.86 | 0.02 | 5.90 | 1.86–18.74 | 0.00 | 5.49 | 2.22–13.56 | 0.00 | 5.82 | 2.36–14.39 | < 0.01 |
> 80 | 52 (12.18) | 8.21 | 1.92–34.99 | 0.00 | 9.46 | 2.87–31.14 | 0.00 | 8.98 | 3.48–23.17 | 0.00 | 9.57 | 3.70–24.72 | < 0.01 |
Gender | |||||||||||||
Female | 101 (23.65) | Reference | Reference | Reference | Reference | ||||||||
Male | 326 (76.35) | 0.89 | 0.60–1.32 | 0.57 | 0.98 | 0.69–1.40 | 0.93 | 0.99 | 0.72–1.36 | 0.94 | 0.99 | 0.72–1.36 | 0.94 |
Epoch of diagnosis | |||||||||||||
2003–2009 | 140 (32.79) | Reference | Reference | Reference | Reference | ||||||||
2010–2016 | 287 (67.21) | 1.15 | 0.79–1.68 | 0.47 | 1.10 | 0.80–1.50 | 0.56 | 1.15 | 0.85–1.55 | 0.36 | 1.15 | 0.85–1.56 | 0.35 |