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Table 1 Clinical and pathological characteristics of the ccRCC patients from the Berazategui Hospital, Argentina. Reference values for Who/ISUP grade, age ranges, MVD index, metastasis, overall survival, local infiltration, tumor size (pT), expression of VEGF-A, HLA-G and ILT4, are provided. The expression levels of markers revealed by IHC were noted as follows: + weak staining; ++ moderate staining; +++ strong staining. Survival, reported as overall survival, is expressed in years considered at 1, 3 or 5 years post-surgery; MVD: Microvessel density index (central and peripheral zone); detection of metastasis: Yes (Y) or Not (N)

From: The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma

Patient Who/ISUP Age Range Metastasis Survival VEGF-A MVD HLA-G ILT4 Local infiltration pT
1 1 70–79 N < 5 + 36 ++ +++ No T1
2 2 50–59 N > 5 + 29 ++ +++ Capsule T2
3 2 60–69 Y < 3 + 14 ++ +++ Renal vein T3
4 2 50–59 N > 5 ++ 24 +++ ++ Capsule T1
5 2 50–59 N > 5 + 38 +++ ++ No T1
6 2 60–69 N > 5 ++ 54 +++ +++ Capsule T1
7 2 60–69 N > 5 +++ 16 ++ +++ Capsule T1
8 2 50–59 N > 5 ++ 33 +++ +++ Capsule T2
9 2 50–59 N > 5 + 35 +++ +++ Capsule T1
10 2 50–59 N > 5 ++ 34 ++ +++ No T1
11 2 50–59 N > 5 + 33 ++ + Capsule T1
12 2 40–49 N > 5 + 42 ++ + No T1
13 2 50–59 N < 5 ++ 31 +++ +++ Perirenal tissues T3
14 3 70–79 N > 5 +++ 20 +++ +++ Renal vein T3
15 3 70–79 Y > 5 ++ 16 ++ +++ Renal vein T3
16 3 50–59 N > 5 + 19 ++ +++ Perirenal tissues T3
17 3 50–59 N < 3 ++ 27 ++ +++ Perirenal tissues T3
18 3 70–79 N > 5 ++ 26 ++ +++ No T1
19 3 50–59 N > 5 + 28 ++ + No T1
20 4 60–69 Y < 1 ++ 26 + +++ Renal vein T3