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Fig. 5 | BMC Cancer

Fig. 5

From: Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells

Fig. 5

Combined blockade of autophagy and APE1 increases chemosensitivity and overcomes cisplatin resistance. a and b Knockdown of APE1 enhanced cisplatin-induced apoptosis in combination with autophagy inhibition by CQ. c Western blotting showed the enhancing effect of APE1 silencing on cisplatin-induced apoptosis in combination with autophagy inhibition by CQ (see Additional file 1: Supplementary Figure 21-26). d Knockdown of APE1 enhanced cisplatin sensitivity in combination with autophagy inhibition in cisplatin-resistant A549 cells. e Knockdown of APE1 enhanced cisplatin-induced apoptosis in combination with autophagy inhibition in cisplatin-resistant A549 cells. f Western blotting showed the enhancing effect of APE1 silencing on cisplatin-induced apoptosis in combination with autophagy inhibition in cisplatin-resistant A549 cells (see Additional file 1: Supplementary Figure 27-31).

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