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Fig. 2 | BMC Cancer

Fig. 2

From: Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells

Fig. 2

Inhibition of autophagy enhances the inhibitory effect of cisplatin in A549 cells. a Inhibition of autophagy by CQ markedly decreased A549 cell viability. The IC50 value was 38.46 μM. b CQ (10 μM) enhanced the inhibitory effect of 0.5 μM cisplatin on cell proliferation. c CQ enhanced the inhibitory effect of cisplatin on cell colony formation. d CQ suppressed the expression level of cisplatin-induced autophagy (see Additional file 1: Supplementary Figure 8-9).

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