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Fig. 8 | BMC Cancer

Fig. 8

From: Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells

Fig. 8

Regulation of bone protein synthesis in breast cancer cell lines. In MDA-MB-231 cells, CDCA binds FXR. FXR dimerizes with another nuclear receptor and activates the bone protein synthesis. In MCF-7 cells, estrogens bind ER and dimerizes with another estrogen receptor. When CDCA is used and binds FXR, FXR dimerizes with ER. The homodimer ER-ER and the heterodimer FXR-ER both activate the bone protein synthesis

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BMC Cancer

ISSN: 1471-2407

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