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Fig. 5 | BMC Cancer

Fig. 5

From: Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells

Fig. 5

Treatments performed on MCF7 cell line: C = control, T = 4-hydroxitamoxifen, F = fulvestrant, L = LCA, E = estrogens, CDCA = chenodeoxycholic acid. a RUNX2, b OPN, c OC and d BSP respective expressions after different treatments. Values represent the mean percentage of mean fluorescence ± SEM of nine independent experiments. For all four markers, the percentage of fluorescence increased after CDCA or estrogens treatment compared to the control values (normalized at 100%). 4-Hydroxytamoxifen and fulvestrant caused an inhibition of the stimulating effect mediated by estrogens. 4-Hydroxytamoxifen, fulvestrant, LCA and Z-guggulsterone administered in combination with CDCA significantly decreased the percentage of fluorescence compared to CDCA used alone (*** p < 0.001, ** p < 0.01, * p < 0.05)

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BMC Cancer

ISSN: 1471-2407

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