Skip to main content

Table 2 Predictors of survival: Univariate and Multivariate survival analyses

From: Pretreatment peripheral neutrophils, lymphocytes and monocytes predict long-term survival in hepatocellular carcinoma

 

Univariate

Multivariate

 

P value

HR (95% CI)

P value

HR (95% CI)

Age (years) ≥ 60

0.002

1.240 (1.085–1.418)

0.153

 

Gender (male)

0.012

1.246 (1.049–1.480)

0.675

 

Etiology (HBV)

< 0.001

0.763 (0.666–0.873)

0.563

 

Alcohol

0.044

1.147 (1.003–1.310)

0.483

 

Smoking

0.155

1.102 (0.964–1.259)

  

Cirrhosis

0.001

1.400 (1.141–1.719)

0.760

 

Tumor number (multiple)

< 0.001

1.610 (1.404–1.845)

0.024

1.262 (1.031–1.545)

Tumor size ≥3.2 (cm)

< 0.001

2.997 (2.591–3.466)

0.036

1.315 (1.018–1.698)

Vascular invasion

< 0.001

7.089 (6.098–8.240)

< 0.001

4.335 (3.326–5.649)

Extrahepatic metastases

< 0.001

5.123 (4.228–6.219)

< 0.001

2.625 (1.925–3.578)

AFP ≥100 (ng/L)a

< 0.001

2.238 (1.946–2.575)

< 0.001

1.501 (1.212–1.859)

PIVKA-II ≥100 (mAU/L)b

< 0.001

3.200 (2.628–3.897)

< 0.001

1.592 (1.247–2.032)

Albumin < 4 (g/dL)

< 0.001

0.400 (0.349–0.458)

< 0.001

2.082 (1.654–2.621)

Total bilirubin ≥0.9 (mg/dL)

< 0.001

1.797 (1.560–2.018)

0.080

 

PT time ≥ 12.8 (sec)

0.007

1.218 (1.169–1.421)

0.108

 

LDH ≥439 (IU/L)c

< 0.001

1.964 (1.716–2.248)

0.032

1.253 (1.020–1.541)

Neutrophil ≥3100 (×106/L)

< 0.001

1.664 (1.454–1.903)

0.006

1.348 (1.089–1.669)

Lymphocyte ≥1640 (×106/L)

< 0.001

0.622 (0.543–0.711)

< 0.001

0.685 (0.559–0.841)

Monocyte ≥470 (×106/L)

< 0.001

1.656 (1.147–1.896)

0.007

1.338 (1.083–1.645)

Platelet ≥145,000 (×106/L)

0.113

1.105 (0.973–1.275)

  
  1. Abbreviations: AFP α-Fetoprotein; HBV Hepatitis B virus; CI Confidence interval; HR Hazard ratio; LDH Lactate dehydrogenase; PIVKA-II Protein induced by vitamin K absence or antagonist-II; PT Pothrombin time
  2. an = 1568, bn = 1089, cn = 1622
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us