Fig. 5
From: Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer
Association of methylation levels of CpG site cg02198582 with survival and resistance acquisition and its correlation with TSC2 expression levels. a Kaplan-Meier plot for CpG site cg02198582 located in the gene body of TSC2 and significantly associated with survival in the AI cohort. Patients were stratified based on methylation levels. H, methylation levels above median; L, methylation levels below median. Shaded areas in the Kaplan-Meier plot denote the 95% CI in the H and L strata. P-value is based on a log-rank test. b Correlation between paired DNA methylation and gene expression profiles (cg02198582, TSC2). Each circle corresponds to a patient sample in the AI cohort. The Pearson correlation coefficient is indicated, together with the corresponding regression line and its 95% CI. c Log2-fold change of the methylation M-values of cg02198582 inT47D LTED versus WT cells