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Fig. 1 | BMC Cancer

Fig. 1

From: Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer

Fig. 1

Study flow chart and cohort definition. This figure shows the steps taken to define each of the three cohorts. First the molecular subtype was determined using TCGA BRCA gene expression data and ER+/HER2- patient samples were selected. Next, patients without follow-up data and patients for whom no methylation profiles were measured were removed. Finally, male patients were removed leading to the study cohort of ER+/HER2- patients. Patients who received tamoxifen form the TAM sub-cohort and patients who received AI form the AI sub-cohort. Dashed arrows indicate filter steps. ‡42 patients received both tamoxifen and AI and are included in both the TAM and AI sub-cohort. No missing data for TAM and AI cohorts. AI, aromatase inhibitor; BRCA, breast invasive carcinoma; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; TAM, tamoxifen; TCGA, The Cancer Genome Atlas

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