Fig. 2

Large-scale ex vivo drug screening in patient derived urachal carcinoma cells. a Scatter plots comparing the GR value correlation of all the drugs in the different test concentrations. A compound library of 1160 drugs was used to assess cytotoxicity on urachal cancer cells following 72-h exposure. Analysis was performed using an imaging cytometry assay and GR scoring. Drugs reducing cell viability more that the proliferation stalling control hydroxyurea (GR < 0) in all concentrations were considered significant. b 49 most effective cytotoxic compounds reducing cell viability (GR < 0) across all test concentrations. GR values of the 3 drug doses stacked and compounds ordered by the averaged cytotoxicity. Drug target/class of each drug is indicated with the different colors