Fig. 2

Consistency in drug sensitivity and resistance between matched patient-derived cell line and PDX tumor. a. High-throughput drug screening using patient-derived cell lines in vitro revealed sensitivity and resistance to a number of commonly-used cytotoxic chemotherapeutic agents (red dots > 50% killing; gray dots between 25 and 50% killing; black dots: < 25% killing). b. In vitro effect of standard-of-care agents (oxaliplatin and irinotecan) were validated on matched PDX tumors (2-way ANOVA: * p = 0.0002)