Fig. 1

Development of patient-derived models of cancer to identify new treatments for metastatic colorectal cancer. a. Clinical characteristics of the six metastatic colorectal cancer patients used to generate the patient-derived models. Tumor tissues of CRC057, CRC119, CRC240, CRC247 and 15–496 were obtained from the liver metastasis; the tissue of 16–159 was obtained from a primary tumor. b. Histological features of the metastatic colorectal cancer PDXs (I-VI); varying degrees of differentiation from well formed glands (IV, V, VI) to sheet of cells without gland formation (I, II, III). Matched PDX cell lines differ in shape: Fibroblast-like (VII), epithelial-like (IX, X) and lymphoblast-like (VIII, XI, XII) cells