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Table 2 Univariate and multivariate survival analysis of RFS and OS in HCC patients with MVI in the study

From: Postoperative adjuvant treatment strategy for hepatocellular carcinoma with microvascular invasion: a non-randomized interventional clinical study

Variable

COX

Univariate analysis

Multivariate analysis

HR (95%CI)

p value

HR (95%CI)

p value

RFS

 Age

0.983 (0.940–1.028)

0.457

  

 Gender

1.624 (0.487–5.416)

0.430

  

 Operative procedure

1.038 (0.438–2.458)

0.933

  

 Operative method

1.116 (0.523–2.382)

0.776

  

 Operative time

0.998 (0.988–1.009)

0.722

  

 Blood loss

1.000 (0.999–1.002)

0.673

  

 Surgical margin

1.325 (0.617–2.843)

0.471

  

 Tumor size

1.171 (0.996–1.378)

0.056

  

 Number of tumors

2.490 (0.854–7.261)

0.095

3.241 (1.077–9.751)

0.036

 Differentiation

1.750 (0.800–3.825)

0.161

  

 MVI classification

3.011 (1.396–6.494)

0.005

3.539 (1.631–7.681)

0.001

 Envelope invasion

2.118 (0.967–4.638)

0.061

  

 Fibrosis S score

1.259 (0.582–2.724)

0.558

  

 HBV-Ag

1.320 (0.397–4.390)

0.651

  

 AFP level

1.544 (0.900–2.650)

0.115

  

 Postoperative treatment strategies

0.337 (0.150–0.759)

0.009

0.286 (0.125–0.651)

0.003

OS

 Age

1.011 (0.950–1.077)

0.724

  

 Gender

0.639 (0.178–2.294)

0.492

  

 Operative procedure

1.676 (0.561–5.007)

0.355

  

 Operative method

0.936 (0.325–2.700)

0.903

  

 Operative time

1.002 (0.989–1.016)

0.743

  

 Blood loss

1.001 (0.999–1.003)

0.312

  

 Surgical margin

1.914 (0.663–5.526)

0.230

  

 Tumor size

1.267 (1.056–1.519)

0.011

1.357 (1.105–1.667)

0.004

 Number of tumors

2.354 (0.524–10.567)

0.264

  

 Differentiation

1.224 (0.424–3.534)

0.709

  

 MVI classification

4.801 (1.601–14.398)

0.005

4.519 (1.460–13.993)

0.009

 Envelope invasion

1.911 (0.639–5.718)

0.247

  

 Fibrosis S score

2.873 (0.800–10.312)

0.106

  

 HBV-Ag

1.987 (0.260–15.202)

0.508

  

 AFP level

1.650 (0.769–3.540)

0.199

  

 Postoperative treatment strategies

0.204 (0.056–0.737)

0.015

0.094 (0.022–0.397)

0.001

  1. HR hazard ratio; CI confidence interval