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Table 1 Patients and Implantation Characteristics

From: Permanent iodine-125 brachytherapy for patients with progressive or recurrent high-grade gliomas

Characteristics SI(n = 29) SRCI(n = 29) p Valuea
Age (yrs)    0.637
 Median (Range) 46 (20–73) 46 (16–70)  
Sex    0.588
 Male 17 (58.6) 19 (65.5)  
 Female 12 (41.4) 10 (34.5)  
KPS 22 (75.9)   
 Median (Range) 80 (50–80) 80 (50–90) 0.401
 90–100 11 (37.9) 8 (27.6)  
  ≤ 80 18 (62.1) 21 (72.4)  
Extent of Resection
 Gross total resection 29 (100) 29 (100)  
 Partial resection 0 (0) 0 (0)  
 Biopsy 0 (0) 0 (0)  
ERBT dose (Gy)
 Median (Range) / 60 (34-70Gy)  
Adjuvant chemotherapy / 11 (37.9)  
Tumor position
 Frontal lobe 6 (20.7) 11 (37.9)  
 Occipital lobe 1 (3.5) 0 (0)  
 Parietal lobe 4 (13.8) 0 (0)  
 Temporal lobe 9 (31.0) 6 (20.7)  
 multi-lobe 9 (31.0) 12 (41.4)  
Tumor location
 Left hemisphere 16 (55.2) 13 (44.8)  
 Right hemisphere 11 (37.9) 16 (55.1)  
 Both hemisphere 2 (6.9) 0 (0)  
Tumor Diameter    0.588
  ≥ 5 cm 12 (41.4) 10 (34.5)  
  < 5 cm 17 (58.6) 19 (65.5)  
Histology    0.753
 WHO III 7 (24.1) 6 (20.7)  
 WHO IV 22 (75.9) 23 (79.3)  
No. of seeds    0.368
 Median (Range) 45 (16–150) 40 (20–98)  
PD (Gy) 110 (100–150) 110 (100–150) 0.655
Symptoms prior to implantation
 Headace 27 (93.1) 27 (93.1) > 0.999
 Nausea 22 (75.9) 18 (62.1) 0.256
 Vomit 14 (48.3) 12 (41.4) 0.597
 Vertigo 6 (20.7) 9 (31.0) 0.368
 Myodynamic    0.387
  ≥ grade 4 22 (75.9) 19 (65.5)  
  < grade 4 7 (24.1) 10 (34.5)  
 Vision 6 (20.7) 10 (34.5) 0.240
 Hearing 5 (17.2) 3 (10.3) 0.446
 Aphasia 6 (20.7) 4 (13.8) 0.487
 Epilepsy 22 (75.9) 11 (37.9) 0.004
 Sensory 3 (10.3) 5 (17.2) 0.446
  1. Note-Date in parentheses are percentages unless indicated
  2. KPS, Karnofsky Perfomance Scale; EBRT, external beam radiotherapy
  3. aχ2 test or Student’s t-test tests were used