Table 1 Resources required per screened woman by intervention arm, with associated costs in 2019 (€ 1 = 10.5912 SEK)

 Pap smear cytological analysis

25

6364

159,100

 Midwife appointment for sampling

98

6364

623,672

 First HPV self-sampling kit, return and HPV test (including postal fees)

27

7997

215,919

 2nd HPV self-sampling kit, return and HPV test (including postal fees)

27

501

13,527

Total cost of primary screening

782,772

229,446

 Screened women

6364

7997

 Abnormal cytology in need of clinical follow-up

222

 2nd HPV-positive in need of clinical follow-up

355

 Incremental effect (screened women)

1633

 Cost per screened woman

123

29

 ICER per extra screened woman

− 339

 Pap smear cytological analysis

25

238

5950

428

10,700

 HPV analysis*

38

173

6574

46

1748

 Midwife appointment for sampling

98

166

16,268

4

392

 Colposcopy appointment

470

114

53,580

384

180,480

 Biopsy histological analysis

147

114

16,758

367

53,949

Total cost of clinical follow-up

99,130

247,269

Total cost of primary screening + clinical follow-up

881,902

476,715

 CIN2+

68

175

 Incremental effect (CIN2+)

107

 Cost per woman with CIN2+

12,969

2724

 ICER per extra detected woman with CIN2+

− 3787

  Participation rate + 25% Pap smear

7955

−5451

  Participation rate + 25% HPV self-sampling

− 3124

9996

  Participation rate − 25% Pap smear

4773

−111

  Participation rate − 25% HPV self-sampling

− 4129

5998

  HPV self-sampling + 25%

34

− 3092

  HPV self-sampling −25%

20

− 4160

  Pap smear cytological analysis + 25%

32

− 3990

  Pap smear cytological analysis −25%

19

− 3262

  Midwife appointment + 25%

122

− 5076

  Midwife appointment −25%

73

− 2176

  Midwife appointment −50%

49

− 727