Fig. 2
From: DNA methylation signatures of Prostate Cancer in peripheral T-cells
Pearson correlation between CG methylation levels (delta beta> 0.1) and Gleason score. a-d A total of 449 CGs’ T cell DNA methylation levels showed to be significantly (Q < 0.05 after FDR correction) correlated with Gleason score (0 for healthy individuals and 6, 8 and 9 for Gleason score 6, 8, 9). Boxplots of mean percentage methylation of the 416 and 33 CGs increasing or decreasing with respect to Gleason score, respectively. b and d Heatmaps of the methylation levels of 416 and 33 CGs that correlate with Gleason score either positively or negatively, respectively. e-h A total of 1181 CGs whose methylation levels significantly (Q < 0.05) correlated with Gleason score when the two cohorts, Cohort 1 and 2, were combined (Combined cohort). (E and F): Boxplots of mean percentage methylation of the 749 and 432 CGs increasing or decreasing with respect to Gleason score, respectively (G and H). Heatmaps of methylation levels of 749 and 432 CGs that correlate with Gleason score either positively or negatively, respectively