Table 5 Univariate and multivariate Cox regression analysis of prognostic value of clinicopathological factors and BCAT1 and CD133 expression for DFS

Age at diagnosis

 ≤ 49

1

 > 49

1.168 (0.759–1.796)

Menopausal status

 Pre-menopause

1

 Post-menopause

1.048 (0.682–1.612)

Histological grade

 I/II

1

 III

0.881 (0.556–1.394)

Tumor size

 pT1

1

NA

 pT2

1.443 (0.907–2.296)

 pT3/pT4

3.770 (1.793–7.930)

Nodal status

 negative

1

NA

 1–3 nodes

1.216 (0.671–2.203)

 4–9 nodes

2.060 (1.018–4.172)

 ≥ 10 nodes

4.586 (2.692–7.812)

TNM Stage

 I

1

1

 II

1.638 (0.892–3.008)

1.744 (0.945–3.22)

 III

4.390 (2.388–8.071)

5.025 (2.722–9.278)

Basal-like phenotype

 Negative

1

 Positive

0.914 (0.496–1.685)

Ki67 index^a

 ≤ 14

1

NA

 > 14

0.530 (0.298–0.943)

TIL

 Low

1

1

 High

0.507 (0.322–0.800)

0.525 (0.328–0.841)

Family History

 Negative

1

 Positive

0.907 (0.332–2.478)

Chemotherapy

 Negative

1

 Positive

1.724 (0.751–3.956)

Radiotherapy

 Negative

1

NA

 Positive

1.846 (1.200–2.840)

LVI

 Negative

1

 Positive

1.630 (0.786–3.380)

BCAT1

 Low expression

1

1

 High expression

2.475 (1.608–3.810)

1.969 (1.259–3.079)

CD133

 Low expression

1

1

 High expression

2.154 (1.399–3.316)

2.42 (1.556–3.764)