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Table 1 The characteristics of studies included in this meta-analysis

From: Body mass index increases the lymph node metastasis risk of breast cancer: a dose-response meta-analysis with 52904 subjects from 20 cohort studies

Author Year Country Age (range) Study period The categories of BMI The number of metastatic tumors The number of non-metastatic tumors NOS
Xiaoyao Zhang 2014 China 53 (27-92) 2010.1-2012.11 BMI <18.5 (underweight)/ 18.5-22.9 (normal)/ 23-24.9 (overweight)/ 25-29.9 (obese)/ BMI≥30 (severe obese) 2/27/21/85/25 7/56/51/115/35 6
Nicoletta Biglia 2013 Italy 45/65 1999.1-2009.12 BMI < 19 (underweight)/ 19-24.9 (normal)/ 25-29.9 (overweight)/ BMI≥30 (obese) 20/141/49/29 (premenopausal) 20/247/217/97 (postmenopausal) 37/200/44/20 (premenopausal) 35/372/243/125 (postmenopausal) 7
Orsolya Hankó-Bauer 2017 Romania 58.29 (27-80) 52.81/60.38/62.8 2012-2015 BMI < 25 (normal weight)/ 25-29.9 (overweight)/ BMI≥30 (obese) 32/40/40 54/48/31 6
Ahmad Kaviani 2013 Iran 49.62 (21-88) 2003-2011 BMI < 24.9 (normal weight)/ 25<BMI<29.9 (overweight)/ BMI<BMI30 (obese) 64/77/42 (premenopausal) 45/68/60 (postmenopausal) 60/52/22 (premenopausal) 39/70/31 (postmenopausal) 7
O.Keskin 2013 Turkey 48.9±10.7 44.5±11.1/ 49.6±11.1/ 52.7±10.0 2001-2011 20-24.9 (normal weight)/ 25-29.9 (overweight)/ BMI≥30 (obese) 231/266/226 198/205/169 7
Geoffrey A. Porter 2006 Canada 60±15.5 2002.2.15- 2004.2.15 BMI <25 (normal/underweight)/ 25-29.9 (overweight)/ BMI≥30 (obese/severely obese) 36/33/46 130/144/130 8
Marianne Ewertz 2011 Denmark --- 1977-2006 BMI <25/ 25-29/ 30+ 6867/3201/1489 4621/1937/849 7
Vincent C. Herlevic 2015 US 61.3 60.5/61.7/61.3 1997-2013 BMI<25 (normal weight)/ 25-30 (overweight)/ BMI>30 (obese) 40/71/142 47/79/144 8
Marian L. Neuhouser 2016 US 50-79 1993-1998 BMI<25 (normal weight)/ 25-30 (overweight)/ 30-35 (obese, Grade 1)/ BMI≥35 (obese, Grade 2+3) 168/245/184/138 (postmenopausal) 579/825/547/345 (postmenopausal) 8
G. Berclaz 2004 International Breast Cancer Study Group 48 (21-84)/ 53 (25-80)/ 55 (26-80) 1978-1993 BMI<24.9 (normal weight)/ 25.0-29.9 (intermediate)/ BMI≥30.0 (obese) 2613/1652/833 695/386/191 6
Vito Michele Garrisi 2012 Italy --- 2004-2006 BMI<24.9 (normal)/ 25-29.99 (overweight)/ BMI≥30 (obese) 43/63/38 63/38/24 6
Luca Mazzarella 2013 European Institute of Oncology --- 1995-2005 BMI <25 (under/normal weight)/ 25-29.99 (overweight)/ BMI≥30 (obese) 258/77/28 (ER positive) 149/66/29 (ER negative) 283/67/31 (ER positive) 159/63/18 (ER negative) 7
Amelia Smith 2018 US 67 (63,73) 1993-2009 BMI < 18.5 (underweight)/ 18.5-24.9 (normal weight)/ 25-29.9 (overweight)/ BMI≥30 (obese) 3/282/261/197 (postmenopausal) 19/869/819/561 (postmenopausal) 6
Kang Wang 2019 China 50.0±11.2 48.5±13.7/ 49.1±11.1/ 52.6±10.7 2005.1-2015.12 BMI<18.5 (underweight)/ 18.5-24.9 (normal weight)/ BMI≥25 (overweight and obese) 114/1644/537 (premenopausal) 70/1120/627 (postmenopausal) 100/1316/422 (premenopausal) 107/1184/559 (postmenopausal) 6
E.R. Copson 2014 UK 36 (18-40) 36 (18-40)/ 37 (18-40)/ 37 (24-40) 2000-2008 BMI<25 (under/healthy weight)/ 25-30 (overweight)/ BMI≥30 (obese) 736/419/284 (premenopausal) 766/354/236 (premenopausal) 7
Aruna Kamineni 2013 US 64.5 (40-93) 1988.1.1- 1993.12.31 BMI<25 (normal weight)/ 25-30 (overweight)/ BMI≥30 (obese) 32/27/12 174/102/66 6
Ronny Mowad 2013 US 49.8 53.2/49.1/49.3 1998.3-2011.9 BMI<25 (normal/underweight)/ 25-29.9 (overweight)/ BMI>30 (obese) 9/18/47 15/24/70 8
Foluso O. Ademuyiwa 2011 US 54 (26-92) 52.9/56.3/56.1 1996.7-2010.7 BMI≤24.9 (normal/underweight)/ 25-29.9 (overweight)/ BMI>30 (obese) 44/49/68 80/81/96 7
Shaheenah Dawood 2008 US 46 (23-76)/ 48 (23-78)/ 52 (28-78) 1974-2000 BMI≤24.9 (normal/underweight)/ 25-29.9 (overweight)/ BMI≥30 (obese) 186/175/186 21/19/16 7
Ozan Yazici 2015 Turkey 48 (18-92) 2002.1-2013.10 18.5-24.9 (normal weight)/ 25-29.9 (overweight)/ BMI≥30.0 (obese) 20/14/7 (premenopausal) 7/5/10 (postmenopausal) 549/393/226 (premenopausal) 228/419/409 (postmenopausal) 7
  1. BMI Body mass index, NOS Newcastle-Ottawa's Scale