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Table 1 The characteristics of studies included in this meta-analysis

From: Body mass index increases the lymph node metastasis risk of breast cancer: a dose-response meta-analysis with 52904 subjects from 20 cohort studies

Author

Year

Country

Age (range)

Study period

The categories of BMI

The number of metastatic tumors

The number of non-metastatic tumors

NOS

Xiaoyao Zhang

2014

China

53 (27-92)

2010.1-2012.11

BMI <18.5 (underweight)/ 18.5-22.9 (normal)/ 23-24.9 (overweight)/ 25-29.9 (obese)/ BMI≥30 (severe obese)

2/27/21/85/25

7/56/51/115/35

6

Nicoletta Biglia

2013

Italy

45/65

1999.1-2009.12

BMI < 19 (underweight)/ 19-24.9 (normal)/ 25-29.9 (overweight)/ BMI≥30 (obese)

20/141/49/29 (premenopausal) 20/247/217/97 (postmenopausal)

37/200/44/20 (premenopausal) 35/372/243/125 (postmenopausal)

7

Orsolya Hankó-Bauer

2017

Romania

58.29 (27-80) 52.81/60.38/62.8

2012-2015

BMI < 25 (normal weight)/ 25-29.9 (overweight)/ BMI≥30 (obese)

32/40/40

54/48/31

6

Ahmad Kaviani

2013

Iran

49.62 (21-88)

2003-2011

BMI < 24.9 (normal weight)/ 25<BMI<29.9 (overweight)/ BMI<BMI30 (obese)

64/77/42 (premenopausal) 45/68/60 (postmenopausal)

60/52/22 (premenopausal) 39/70/31 (postmenopausal)

7

O.Keskin

2013

Turkey

48.9±10.7 44.5±11.1/ 49.6±11.1/ 52.7±10.0

2001-2011

20-24.9 (normal weight)/ 25-29.9 (overweight)/ BMI≥30 (obese)

231/266/226

198/205/169

7

Geoffrey A. Porter

2006

Canada

60±15.5

2002.2.15- 2004.2.15

BMI <25 (normal/underweight)/ 25-29.9 (overweight)/ BMI≥30 (obese/severely obese)

36/33/46

130/144/130

8

Marianne Ewertz

2011

Denmark

---

1977-2006

BMI <25/ 25-29/ 30+

6867/3201/1489

4621/1937/849

7

Vincent C. Herlevic

2015

US

61.3 60.5/61.7/61.3

1997-2013

BMI<25 (normal weight)/ 25-30 (overweight)/ BMI>30 (obese)

40/71/142

47/79/144

8

Marian L. Neuhouser

2016

US

50-79

1993-1998

BMI<25 (normal weight)/ 25-30 (overweight)/ 30-35 (obese, Grade 1)/ BMI≥35 (obese, Grade 2+3)

168/245/184/138 (postmenopausal)

579/825/547/345 (postmenopausal)

8

G. Berclaz

2004

International Breast Cancer Study Group

48 (21-84)/ 53 (25-80)/ 55 (26-80)

1978-1993

BMI<24.9 (normal weight)/ 25.0-29.9 (intermediate)/ BMI≥30.0 (obese)

2613/1652/833

695/386/191

6

Vito Michele Garrisi

2012

Italy

---

2004-2006

BMI<24.9 (normal)/ 25-29.99 (overweight)/ BMI≥30 (obese)

43/63/38

63/38/24

6

Luca Mazzarella

2013

European Institute of Oncology

---

1995-2005

BMI <25 (under/normal weight)/ 25-29.99 (overweight)/ BMI≥30 (obese)

258/77/28 (ER positive) 149/66/29 (ER negative)

283/67/31 (ER positive) 159/63/18 (ER negative)

7

Amelia Smith

2018

US

67 (63,73)

1993-2009

BMI < 18.5 (underweight)/ 18.5-24.9 (normal weight)/ 25-29.9 (overweight)/ BMI≥30 (obese)

3/282/261/197 (postmenopausal)

19/869/819/561 (postmenopausal)

6

Kang Wang

2019

China

50.0±11.2 48.5±13.7/ 49.1±11.1/ 52.6±10.7

2005.1-2015.12

BMI<18.5 (underweight)/ 18.5-24.9 (normal weight)/ BMI≥25 (overweight and obese)

114/1644/537 (premenopausal) 70/1120/627 (postmenopausal)

100/1316/422 (premenopausal) 107/1184/559 (postmenopausal)

6

E.R. Copson

2014

UK

36 (18-40) 36 (18-40)/ 37 (18-40)/ 37 (24-40)

2000-2008

BMI<25 (under/healthy weight)/ 25-30 (overweight)/ BMI≥30 (obese)

736/419/284 (premenopausal)

766/354/236 (premenopausal)

7

Aruna Kamineni

2013

US

64.5 (40-93)

1988.1.1- 1993.12.31

BMI<25 (normal weight)/ 25-30 (overweight)/ BMI≥30 (obese)

32/27/12

174/102/66

6

Ronny Mowad

2013

US

49.8 53.2/49.1/49.3

1998.3-2011.9

BMI<25 (normal/underweight)/ 25-29.9 (overweight)/ BMI>30 (obese)

9/18/47

15/24/70

8

Foluso O. Ademuyiwa

2011

US

54 (26-92) 52.9/56.3/56.1

1996.7-2010.7

BMI≤24.9 (normal/underweight)/ 25-29.9 (overweight)/ BMI>30 (obese)

44/49/68

80/81/96

7

Shaheenah Dawood

2008

US

46 (23-76)/ 48 (23-78)/ 52 (28-78)

1974-2000

BMI≤24.9 (normal/underweight)/ 25-29.9 (overweight)/ BMI≥30 (obese)

186/175/186

21/19/16

7

Ozan Yazici

2015

Turkey

48 (18-92)

2002.1-2013.10

18.5-24.9 (normal weight)/ 25-29.9 (overweight)/ BMI≥30.0 (obese)

20/14/7 (premenopausal) 7/5/10 (postmenopausal)

549/393/226 (premenopausal) 228/419/409 (postmenopausal)

7

  1. BMI Body mass index, NOS Newcastle-Ottawa's Scale