A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report

Table 1 Gene mutational profile of the spinal astrocytoma patient by next-generation sequencing

	mutation	Mutation abundance (%)/copy number
CDK4	amplification	32
WEE1	c.1385-1G > A	38.30%
MDM2	amplification	37
PTPN11	p.E69K	31.30%
FRS2	amplification	37
GLI1	amplification	32

Abbreviations: CDK4 = cyclin dependent kinase 4, WEE1 = WEE1 G2 checkpoint kinase, MDM2 = MDM2 proto-oncogene, PTPN11 = protein tyrosine phosphatase non-receptor type 11, FRS2 = fibroblast growth factor receptor substrate 2, GLI1 = GLI family zinc finger 1

ISSN: 1471-2407