Skip to main content

Table 1 Gene mutational profile of the spinal astrocytoma patient by next-generation sequencing

From: A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report

  mutation Mutation abundance (%)/copy number
CDK4 amplification 32
WEE1 c.1385-1G > A 38.30%
MDM2 amplification 37
PTPN11 p.E69K 31.30%
FRS2 amplification 37
GLI1 amplification 32
  1. Abbreviations: CDK4 = cyclin dependent kinase 4, WEE1 = WEE1 G2 checkpoint kinase, MDM2 =  MDM2 proto-oncogene, PTPN11 = protein tyrosine phosphatase non-receptor type 11, FRS2 = fibroblast growth factor receptor substrate 2, GLI1 = GLI family zinc finger 1