TY - JOUR AU - Lin, Jietao AU - Yu, Ling AU - Fu, Yuanfeng AU - Chen, Hanrui AU - Zheng, Xinting AU - Wang, Shutang AU - Gao, Chan AU - Cao, Yang AU - Lin, Lizhu PY - 2020 DA - 2020/07/08 TI - A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report JO - BMC Cancer SP - 630 VL - 20 IS - 1 AB - Spinal cord astrocytoma is a rare neoplasm, and patients usually recur within months after surgery. There is currently a lack of consensus regarding post-operative treatment. Clinical data on the activity of systemic treatment like chemoradiotherapy and anti-angiogenic agents also remained scant. Next-generation sequencing (NGS) -based genomic profiling thus may help identify potential treatment options for a subset of patients that harbor actionable genetic alterations. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-020-07061-3 DO - 10.1186/s12885-020-07061-3 ID - Lin2020 ER -