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Table 4 Results of subgroup analyses on OS and RFS

From: Prognostic value of circulating tumor cells detected with the CellSearch system in esophageal cancer patients: a systematic review and meta-analysis

Variable

OS

RFS

n

HR (95% CI)

P-valuea

I2

P-valueb

n

HR (95% CI)

P-valuea

I2

P-valueb

Yearc

 > Median

2

2.93 (1.62,5.31)

<0.001

0%

0.7

1

4.04 (1.86,8.78)

<0.001

–

–

 ≤ Median

6

2.78 (1.79,4.30)

<0.001

0%

43%

2

5.48 (2.54,11.79)

<0.001

0%

0.59

Country

 East Asia

4

3.34 (1.58,7.09)

0.002

12%

0.33

0

–

–

–

–

 non-East Asia

4

2.68 (1.76,4.08)

<0.001

0%

0.69

3

4.71 (2.73,8.13)

<0.001

0%

0.75

Patient no.d

 >Median

4

2.89 (1.93,4.31)

<0.001

0%

0.96

1

5.06 (2.23,11.48)

<0.001

–

–

  ≤ Median

4

2.89 (1.03,8.13)

0.04

37%

0.19

2

4.45 (2.15,9.24)

<0.001

0%

0.47

Sampling time

 Baseline

7

2.85 (2.00,4.07)

<0.001

0%

0.54

3

4.71 (2.73,8.13)

<0.001

0%

0.75

 intra-therapy

1

2.04 (0.18,23.12)

0.56

–

–

0

–

–

–

–

Cutoff value

  ≥ 1/7.5 ml

4

2.89 (1.93,4.31)

<0.001

0%

0.96

3

4.71 (2.73,8.13)

<0.001

0%

0.75

  ≥ 2/7.5 ml

4

2.89 (1.03,8.13)

0.04

37%

0.19

0

–

–

–

–

Positive ratee

 >Median

4

2.09 (1.17,3.74)

0.01

0%

0.91

1

4.04 (1.86,8.78)

<0.001

–

–

  ≤ Median

4

3.38 (2.17,5.26)

<0.001

0%

0.41

2

5.48 (2.54,11.79)

<0.001

0%

0.59

Quality

 High

7

2.61 (1.82,3.75)

<0.001

0%

0.95

3

4.71 (2.73,8.13)

<0.001

0%

0.75

 Low

1

11.12 (2.51,49.26)

–

–

0.17

0

–

–

–

–

Overall

8

2.83 (1.99,4.03)

<0.001

0%

0.65

3

4.71 (2.73,8.13)

<0.001

0%

0.75

  1. aP-value for estimates of HR.
  2. bP-value for heterogeneity
  3. c The median year of Os and PFs was 2015 and 2018, respectively
  4. d The median patient number of Os and PFs was 41.5 and 76, respectively
  5. e The median positive rate of Os and PFs was 23.8 and 18%, respectively
  6. “-”: not available
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BMC Cancer

ISSN: 1471-2407

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