Fig. 5

High expression of Mig-6 is correlated with poor prognosis and EMT in lung cancer. a Overall survival of lung adenocarcinoma patients was compared between Mig-6-high and Mig-6-low expression groups. Histograms of Mig-6 gene expression in lung adenocarcinoma patients. Vertical red lines designate 9.887 as the optimal cutoff of mRNA derived from the log-rank test. High mRNA expression of Mig-6 was significantly associated with a poor prognosis (hazard ratio [HR]: 1.92 [95% confidence interval (CI): 1.29–2.85]). Subgroup analysis was performed in patients with or without EGFR mutation. High mRNA expression of Mig-6 without EGFR mutation was significantly associated with poor prognosis (HR: 1.86 [95% CI: 1.19–2.9]). High mRNA expression of Mig-6 with EGFR mutation was also significantly associated with poor prognosis (HR: 2.33 [95% CI: 0.97–5.59]). b The graph displays the enrichment gene set based on the hallmark and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in the top 10% vs. bottom 10% groups of Mig-6 in lung adenocarcinoma patients. Gene Set Enrichment Analysis of the EMT, G2M checkpoint, hypoxia, TGF-β, cell cycle, and ERBB signature genes in the high and low Mig-6 expression groups of lung adenocarcinoma patients