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Fig. 7 | BMC Cancer

Fig. 7

From: The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer

Fig. 7

The involvement of the miR-130a-5p/RUNX2/STK32A network in NSCLC. a STK32A mRNA in A549 and SK-MES-1 cells transfected with miR-130a-5p mimic, miR-130a-5p mimic + pcDNA RUNX2 and its controls determined by RT-qPCR (one-way ANOVA, *p < 0.05); b the extent of NF-κB p65 phosphorylation in A549 cells determined by western blot (one-way ANOVA, *p < 0.05); c A549 cell proliferation tested by CCK-8 (two-way ANOVA, *p < 0.05) and colony formation assays (one-way ANOVA, *p < 0.05); d A549 cell migration and invasion evaluated by Transwell assay (one-way ANOVA, *p < 0.05); e, cell apoptosis determined by flow cytometry (one-way ANOVA, *p < 0.05); f, tumor weight and volume of nude mice injected with A549 cells transfected with miR-130a-5p mimic, miR-130a-5p mimic + pcDNA RUNX2 and its controls (one-way ANOVA, *p < 0.05)

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