Table 3 Association of LINE-1ORF1p expression with clinicopathological parameters in MM
Clinicopathological characteristics | Total Number (%) | ORF1P expression (mean H-score = 46.27) | P value | ||
|---|---|---|---|---|---|
High | Low | ||||
Mean age ± SD (65.1 ± 14.2 years) | > 65 | 15 (48.4) | 5 (33.3) | 10 (66.7) | 0.60 |
≤65 | 16 (51.6) | 4 (25) | 12 (75) | ||
Gender | Male | 18 (58.1) | 6 (33.3) | 12 (66.7) | 0.53 |
Female | 13 (41.9) | 3 (23.1) | 10 (76.9) | ||
Ulceration | Yes | 6 (19.4) | 0 | 6 (100) | 0.07 |
No | 18 (58.1) | 7 (38.9) | 11 (61.1) | ||
No data | 7 (22.6) | 2 (28.6) | 5 (71.4) | ||
Perineural invasion (PNI) | Yes | 3 (9.7) | 0 | 3 (100) | 0.21 |
No | 20 (64.5) | 7 (35) | 13 (65) | ||
No data | 8 (25.8) | 2 (25) | 6 (75) | ||
Metastasis | Yes | 12 (38.7) | 6 (50) | 6 (50) | 0.26 |
No | 8 (25.8) | 2 (25) | 6 (75) | ||
No data | 11 (35.5) | 1 (9.1) | 10 (90.9) | ||
Local recurrence | Yes | 17 (54.8) | 7 (41.2) | 10 (58.8) | 0.16 |
No | 3 (9.7) | 0 | 3 (100) | ||
No data | 11 (35.5) | 2 (18.2) | 9 (81.8) | ||
Tumor-infiltrating lymphocytes | Yes | 6 (19.4) | 0 | 6 (100) | 0.19 |
No | 4 (12.9) | 1 (25) | 3 (75) | ||
No data | 21 (67.7) | 8 (38.1) | 13 (61.9) | ||
Lymphovascular invasion | Yes | 7 (22.6) | 1 (14.3) | 6 (85.7) | 0.79 |
No | 5 (16.1) | 1 (20) | 4 (80) | ||
No data | 19 (61.3) | 7 (36.8) | 12 (63.2) | ||
Margin involvement | Yes | 7 (23.3) | 2 (28.6) | 5 (71.4) | 0.5 |
No | 18 (60) | 3 (16.7) | 15 (83.3) | ||
No data | 6 (16.7) | 4 (66.7) | 2 (33.3) | ||
Breslow thickness | Thin (≤1 mm) | 2 (6.5) | 0 | 2 (100) | 0.59 |
Thick (> 1 mm) | 8 (25.8) | 1 (12.5) | 7 (87.5) | ||
No data | 21 (67.7) | 8 (38.1) | 13 (61.9) | ||
Clark level | Group 1 (I, II) | 7 (22.6) | 1 (14.3) | 6 (85.7) | 0.33 |
Group 2 (III-V) | 6 (19.4) | 0 | 6 (100) | ||
No data | 18 (58.1) | 8 (44.4) | 10 (55.6) | ||