Table 1 Diagnostic ability of serum bone biomarkers to distinguish lung cancer patients with bone metastasis from those without bone involvement
Cut-off | Sensitivity | Specificity | Diagnostic | ||||
|---|---|---|---|---|---|---|---|
Marker | AUC | 95% CI | level | % | % | P value | accuracy (%) |
BME cytokine | |||||||
CaN (ng/mL) | 0.81 | 0.747–0.859 | 1257.80 | 81.10 | 75.60 | < 0.001 | 78.74 |
OPG (ng/mL) | 0.83 | 0.760–0.856 | 1547.00 | 77.20 | 78.20 | < 0.001 | 77.30 |
PTHrP (pg/mL) | 0.85 | 0.798–0.899 | 322.30 | 95.30 | 73.10 | < 0.001 | 51.70 |
IL-6 (pg/mL) | 0.65 | 0.583–0.717 | 14.36 | 72.40 | 55.10 | < 0.001 | 65.90 |
Bone turnover marker | |||||||
tP1NP (μg/L) | 0.84 | 0.780–0.885 | 93.59 | 66.90 | 91.00 | < 0.001 | 74.71 |
β-CTx (ng/L) | 0.81 | 0.749–0.865 | 619.70 | 80.30 | 82.10 | < 0.001 | 83.91 |