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Fig. 2 | BMC Cancer

Fig. 2

From: Immune characterization of metastatic colorectal cancer patients post reovirus administration

Fig. 2

a shows the relative change in cytokine expression (by mean expression across all reovirus-treated patients) over time. Statistically significant increases were observed at day 8 for IL-12p40 (p=0.05) and IL-15 (p=0.05); day 15 for GM-CSF (p=0.009) and IL-12p70 (p=0.02). Abbreviations: POST=post-reovirus administration; h=hours; D=Day. Error bars represent the standard error of the mean values. b shows the relative change in cytokine expression (by mean expression across all reovirus-treated patients) over time. Statistically significant reductions were observed at 72 hours, 96 hours, day 8 and day 15 for IL-8 (p=0.02; p=0.00003; p=0.00000001; p=0.03); day 15 for RANTES (p=0.003); 24 hours, 48 hours and 72 hours for VEGF (p=0.0002; 0.007; 0.002). Statistically significant increases were observed for the POST and day 8 timepoints for IL-6 (p=0.04; p=0.00007). Abbreviations: POST=post-reovirus administration; h=hours; D=Day. Error bars represent the standard error of the mean values

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