Fig. 1

a shows the relative change in exosomal miRNA expression (by mean Cq value across all patients) over time. Statistically significant increases in mean Cq (signifying decreases in the quantity of miRNA) were observed at 48 hours (p=0.004), day 8 (p=0.003), and day 15 (p=0.0001) for patients treated with reovirus. Abbreviations: PRE=pre-reovirus administration (baseline); 48h=48 hours; D=Day; REO=patients treated with reovirus; Non-REO=patients treated with background therapy (i.e., bevacizumab and FOLFIRI) only. Error bars represent the standard error of the mean. b shows the relative change in cellular miRNA expression (by mean Cq value across all patients) over time. A statistically significant increase in mean Cq (signifying a decrease in the quantity of miRNA) was observed at 48 hours (p=0.002) for patients treated with reovirus. Abbreviations: PRE=prereovirus administration (baseline); 48h=48 hours; D=Day; REO=patients treated with reovirus; Non-REO=patients treated with background therapy (i.e., bevacizumab + FOLFIRI) only Error bars represent the standard error of the mean