Table 4 Univariate and multivariate Cox regression analysis of prognostic factors for overall survival and disease-free survival in patients with rectal cancer
Variable | Overall survival | Disease-free survival | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate HR (95% CI) | p value | Multivariate HR (95% CI) | p value | Univariate HR (95% CI) | p value | Multivariate HR (95% CI) | p value | |
Age (< 60/≥60 y) | 1.196 (0.560–2.554) | 0.645 | 2.411 (0.953–6.102) | 0.063 | 1.152 (0.539–2.461) | 0.715 | 2.444 (0.960–6.220) | 0.061 |
Gender (Male/Female) | 0.574 (0.242–1.356) | 0.206 | 0.766 (0.295–1.988) | 0.583 | 0.572 (0.242–1.352) | 0.203 | 0.759 (0.295–1.949) | 0.566 |
CEA (< 5/≥5 ng/ml) | 1.999 (0.944–4.232) | 0.07 | 1.054 (0.438–2.536) | 0.907 | 2.148 (1.013–4.553) | 0.046 | 1.186 (0.492–2.859) | 0.704 |
Distance from anal verge (< 6/≥6 cm) * | 0.687 (0.323–1.461) | 0.329 | 0.493 (0.190–1.283) | 0.147 | 0.657 (0.309–1.398) | 0.275 | 0.428 (0.165–1.108) | 0.08 |
Neoadjuvant chemoradiotherapy (No/Yes) | 2.939 (1.375–6.281) | 0.005 | 3.119 (1.256–7.744) | 0.014 | 3.096 (1.447–6.620) | 0.004 | 3.604 (1.450–8.958) | 0.006 |
Maximum size (< 3/≥3 cm)* | 1.506 (0.637–3.562) | 0.351 | 1.448 (0.521–4.026) | 0.478 | 1.532 (0.648–3.624) | 0.331 | 1.511 (0.507–4.508) | 0.459 |
No. of total mesenteric lymph nodes harvested (< 12/≥12) | 1.350 (0.570–3.200) | 0.495 | 1.726 (0.509–5.855) | 0.381 | 1.494 (0.632–3.534) | 0.361 | 1.898 (0.572–6.305) | 0.295 |
No. of PCNs (< 2/≥2) | 1.124 (0.524–2.414) | 0.764 | 0.681 (0.227–2.048) | 0.494 | 1.239 (0.582–2.637) | 0.578 | 0.580 (0.178–1.897) | 0.368 |
No. of SPLNs (< 6/≥6) | 0.928 (0.432–1.993) | 0.847 | 0.606 (0.211–1.739) | 0.352 | 1.039 (0.486–2.221) | 0.921 | 0.557 (0.191–1.623) | 0.283 |
No. of MLNs (< 2/≥2) | 1.410 (0.648–3.071) | 0.387 | 2.304 (0.867–6.122) | 0.094 | 1.597 (0.741–3.442) | 0.232 | 2.317 (0.865–6.207) | 0.095 |
Pericolic lymph nodes metastasis beyond 10 cm proximal to the tumor (No/Yes) | v4.689 (1.775–12.386) | 0.002 | 4.433 (1.124–17.485) | 0.033 | 5.799 (2.190–15.352) | < 0.001 | 6.703 (1.508–29.795) | 0.012 |
pT stage (T0–2/T3–4) | 2.346 (0.555–9.917) | 0.246 | 2.808 (0.543–14.534) | 0.218 | 2.401 (0.568–10.142) | 0.234 | 2.694 (0.516–14.072) | 0.24 |
pN stage (N0/N1–2) | 2.940 (1.364–6.335) | 0.006 | 2.033 (0.918–4.504) | 0.08 | 3.294 (1.527–7.103) | 0.002 | 2.606 (1.084–6.266) | 0.032 |
pTNM stage (0-II/III-IV) | 4.418 (1.934–10.094) | < 0.001 | 12.053 (2.782–52.223) | 0.001 | 5.129 (2.242–11.733) | < 0.001 | 21.327 (4.322–105.224) | < 0.001 |
Histological type (G1–2/G3–4) | 1.104 (0.481–2.533) | 0.815 | 0.608 (0.209–1.763) | 0.359 | 1.238 (0.542–2.829) | 0.612 | 0.682 (0.229–2.033) | 0.492 |
Cancer nodule (No/Yes) | 2.589 (1.094–6.124) | 0.03 | 1.494 (0.436–5.127) | 0.523 | 2.963 (1.250–7.022) | 0.014 | 1.703 (0.495–5.859) | 0.398 |
Vascular invasion (No/Yes) | 1.312 (0.395–4.364) | 0.657 | 0.541 (0.142–2.063) | 0.368 | 1.351 (0.407–4.486) | 0.624 | 0.653 (0.177–2.406) | 0.522 |
Nerve invasion (No/Yes) | 1.702 (0.717–4.039) | 0.228 | 1.151 (0.434–3.055) | 0.777 | 1.667 (0.705–3.944) | 0.245 | 1.154 (0.441–3.017) | 0.77 |
Circumferential resection margin (Negative/Positive) | 3.013 (0.712–12.753) | 0.134 | 2.049 (0.379–11.064) | 0.404 | 2.734 (0.646–11.569) | 0.172 | 0.781 (0.134–4.568) | 0.784 |