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Table 2 Associations between plasma n-3 PUFAs and endometrial cancer recurrencea

From: Plasma omega-3 polyunsaturated fatty acids and recurrence of endometrial cancer

Variable

Tertile1

Tertile2

Tertile3

P-trendb

C18:3n3

 wt%

0.62(0.54–0.67)

0.86(0.79–0.93)

1.23(1.07–1.33)

 

 Events/total(n/n)

3/65

5/66

5/64

 

 Model 1

1.00

1.87(0.43–8.1)

1.94(0.45–8.37)

0.43

 Model 2

1.00

1.74(0.41–7.4)

3.78(0.87–16.41)

0.07

 Model 3

1.00

2.15(0.48–9.66)

3.28(0.7–15.41)

0.13

C20:5n3

 wt%

0.31(0.26–0.36)

0.53(0.46–0.6)

0.84(0.73–1.02)

 

 Events/total(n/n)

1/65

3/66

9/64

 

 Model 1

1.00

2.88(0.3–27.74)

9.71(1.23–76.73)

0.01

 Model 2

1.00

2.83(0.29–27.34)

7.3(0.89–59.68)

0.03

 Model 3

1.00

1.98(0.19–21.12)

6.02(0.7–52.06)

0.04

C22:5n3

 wt%

0.39(0.35–0.42)

0.5(0.46–0.54)

0.63(0.6–0.7)

 

 Events/total(n/n)

1/65

6/66

6/64

 

 Model 1

1.00

6.57(0.78–55.51)

6.61(0.79–55.1)

0.1

 Model 2

1.00

8.48(0.99–72.72)

7.82(0.93–65.77)

0.06

 Model 3

1.00

7.02(0.73–67.61)

7.19(0.81–64.1)

0.1

C22:6n3

 wt%

2.04(1.74–2.21)

2.62(2.47–2.82)

3.39(3.11–4)

 

 Events/total(n/n)

2/65

7/66

4/64

 

 Model 1

1.00

3.14(0.65–15.13)

1.97(0.36–10.86)

0.6

 Model 2

1.00

3.25(0.66–15.89)

1.59(0.29–8.82)

0.87

 Model 3

1.00

3.25(0.61–17.31)

1.22(0.2–7.54)

0.77

HUFA

 wt%

2.88(2.61–3.06)

3.65(3.48–3.84)

4.8(4.31–5.67)

 

 Events/total(n/n)

2/65

4/66

7/64

 

 Model 1

1.00

1.77(0.32–9.67)

3.56(0.73–17.29)

0.09

 Model 2

1.00

1.69(0.3–9.42)

2.55(0.52–12.59)

0.23

 Model 3

1.00

1.57(0.27–9.14)

2(0.38–10.54)

0.42

Total n-3 PUFA

 wt%

3.68(3.42–3.93)

4.53(4.35–4.72)

5.79(5.22–6.65)

 

 Events/total(n/n)

3/65

3/66

7/64

 

 Model 1

1.00

0.95(0.19–4.72)

2.4(0.62–9.37)

0.15

 Model 2

1.00

0.96(0.19–4.83)

2.3(0.59–9.02)

0.17

 Model 3

1.00

0.77(0.14–4.19)

1.7(0.4–7.33)

0.32

  1. Abbreviation: PUFA Polyunsaturated Fatty Acids, HUFA Highly Unsaturated Fatty Acid
  2. aHUFA was defined as EPA + DPA + DHA. Total omega-3 PUFA was defined as ALA+EPA + DPA + DHA. Cox regression was used to estimate the HRs and CIs. PUFAs were classified into three groups based on the tertiles in total subjects, the lowest tertile group was treated as reference
  3. bP-trend values were conducted by assigning the median value to each tertile in the Cox regression models
  4. Model 1: adjusting for age
  5. Model 2: adjusting for age, BMI, and stage
  6. Model 3: adjusting for age, BMI, stage, hormone therapy, and adjuvant therapy