Table 1 Sensitivity of leukemia cell lines to cytostatic drugs

HPB-ALL

T-ALL

0.000192

0.049900

0.111165

IC50 ASNase [IU/ml]

IC50 VCR [μM]

IC50 DNR [μM]

IC50 ASNase [IU/ml]

IC50 VCR [μM]

IC50 DNR [μM]

REH

B-ALL

0.000231

0.000420

0.007571

B-ALL

0.000677

0.001601

0.004953

0.1206 ± 0.0613

0.001437 ± 0.000376

0.007675 ± 0.001731

RS4;11

B-ALL

0.000378

0.002049

0.004953

T-ALL

0.3061

0.003056

0.03728

0.2677 ± 0.1099

0.014600 ± 0.011770

0.051480 ± 0.021210

SUP-B15

B-ALL

0.000549

0.000428

0.004655

AML

0.4385

0.001399

0.006661

0.4344 ± 0.0779

0.001615 ± 0.000562

0.014400 ± 0.006673

HB11;19

B-ALL

0.000677

0.002534

0.004509

TOM-1

B-ALL

0.158103

0.001601

0.003750

MOLT-4

T-ALL

0.175502

0.002784

0.052362

THP-1

AML

0.200475

0.001399

0.039269

NALM-6

B-ALL

0.328894

0.002578

0.013874

MV4–11

AML

0.336387

0.003011

0.017245

UOC-B6

B-ALL

0.355603

0.000450

0.014414

JURKAT

T-ALL

0.436766

0.002393

0.022205

KASUMI-1

AML

0.438479

0.002823

0.006661

CCRF-CEM

T-ALL

0.458528

0.003328

0.020190

MOLM-13

AML

0.557342

0.000418

0.002844

LAMA-84

CML in blast crisis (manifests as ALL)

0.611470

0.019001

0.109103

NB4

AML

0.639279

0.000424

0.005995

BV-173

CML in blast crisis (manifests as ALL)

0.654297

0.003051

0.023315

K-562

CML in blast crisis (manifests as AML)

0.715221

0.018563

0.048036