Fig. 3

Functional study on the correlation between ATP synthase activity and sensitivity to ASNase. a Effect of Oligomycin A (20 nM) on the sensitivity of leukemia cell lines (REH, NALM-6, MV4;11, JURKAT and HPB-ALL) to ASNase. b Effect of Oligomycin A (20 nM) on the sensitivity of leukemia cell lines (NALM-6, MV4;11) to VCR and DNR. Cells were pre-treated with Oligomycin A for 1 h or left untreated and then co-treated with ASNase (or VCR, DNR) for the indicated time (48 h; JURKAT and HPB-ALL for 72 h). Absolute cell counts were obtained from 3 independent experiments; data were normalized to untreated controls and are presented as mean ± SD