Fig. 2

Association between the metabolic profile of the leukemia cells and the sensitivity to cytostatic drugs. a Spearman rank correlation calculations of leukemia cell lines IC50 of ASNase [IU/ml] with VCR [μM], ASNase [IU/ml] with DNR [μM], VCR [μM] with DNR [μM], followed by a Bonferroni multiple comparison test. b, c Canonical correlation analysis: we specified all the metabolic parameters as the first set of variables and IC50 of ASNase (or IC50 of DNR) plus leukemia cell types as the second set. Variables 1, which are mostly correlated with variables 2, are highlighted. Canonical coefficients are displayed across all sets of variables. Their values can differ due to different types of parameters. Negative or positive coefficients express negative or positive correlations with parameters from the other set (b) The strongest influence from variable set 1 were OCR/ECAR, basal respiration and ATP-linked respiration and from variable set 2 were IC50 and cell type. c The strongest influences from variable set 1 were FAO, basal respiration and ATP-linked respiration and from variable set 2 were IC50 and cell type