Categories | Studies(n) | Number of patients | HR (95% CI) | p-value | Heterogeneity | ||
---|---|---|---|---|---|---|---|
I2 (%) | PQ | Model | |||||
All | 11 | 1547 | 1.94(1.60–2.35) | < 0.0001 | 32.6 | 0.139 | Fixed |
Cutoff value for high expression | |||||||
 Final staining scores: 4 or 5 | 7 | 1118 | 2.03(1.42–2.19) | < 0.0001 | 40.9 | 0.119 | Fixed |
 Final staining scores: 3 | 2 | 231 | 4.27(1.83–9.95) | 0.001 | 0.0 | 0.604 | Fixed |
 Others | 2 | 198 | 2.10(1.44–3.06) | < 0.0001 | 0.0 | 0.571 | Fixed |
Analysis type | |||||||
 Multivariate | 10 | 1404 | 2.20(1.66–2.93) | < 0.0001 | 39.0 | 0.098 | Fixed |
 Survival curves | 1 | 143 | 8.66(1.10–68.22) | 0.001 | – | – | – |
Sample size | |||||||
 ≥100 | 10 | 1479 | 2.29(1.68–3.12) | < 0.0001 | 44.9 | 0.060 | Fixed |
 < 100 | 1 | 68 | 2.82(1.04–9.13) | 0.041 | – | – | – |