Expression of tripartite motif-containing 44 and its prognostic and clinicopathological value in human malignancies:a meta-analysis

Table 1 Characteristics of included studies

Author	Year	Disease	Country	Sample size	Over-expression (N, %)	Detection method	Evaluation standard of TRIM44 overexpression	End-points (analysis type)	Follow-up	NOS score
Kashimoto K	2012	GC	Japan	112	28, 25%	IHC	Final staining scores^a ≥ 4	OS (M)	NR	8
Kawabata H	2017	BC	Japan	129	67, 52%	IHC	Final staining scores^a ≥ 5	OS (M)	≥ 5 years	9
Kawaguchi T	2017	EC	Japan	68	39, 57%	IHC	Final staining scores^b ≥ 1	OS (M)	≥ 5 years	9
Li P	2018	EMC	China	143	80, 56%	IHC	Final staining scores^a ≥ 4	OS (C)	≥ 5 years	7
Liu S	2018	EOC	China	109	93, 85%	IHC	Final staining scores^a ≥ 3	OS (M), DFS (M)	≥ 5 years	7
Peng R	2018	ICC	China	130	71, 55%	IHC	Percentage of TRIM44 positive cells ≥50%	OS (M)	≥ 5 years	8
Xing Y	2016	NSCLC	China	331	208, 63%	IHC	Final staining scores^c ≥ 4	OS (M), DFS (M)	≥ 5 years	9
Xiong D	2018	EC	China	100	53, 53%	IHC	Final staining scores^c ≥ 4	OS (M)	≥ 5 years	8
Yamada Y	2017	TGCT	Japan	103	41, 40%	IHC	Intensity score ≥ 1	NR	NR	7
Zhu X	2016	HCC	China	106	73, 69%	IHC	Final staining scores^c ≥ 5	OS (M)	≥ 5 years	8
Liu S	2019	CC	China	122	81, 66%	IHC	Final staining scores^a ≥ 3	OS (M), DFS (M)	≥ 5 years	7
Wei CY	2019	Melanoma	China	197	98, 50%	IHC	integrated optical density value(≥ median value)	OS (M), DFS (M)	≥ 5 years	7
Wang H	2018	Osteosarcoma	China	90	53, 58.9%	IHC	Final staining scores ^a > 5	NR	NR	8

Abbreviations: GC Gastric cancer, BC Breast cancer, EC Esophageal cancer, EMC Endometrial carcinoma, EOC Epithelial ovarian cancer, ICC Intrahepatic cholangiocarcinoma, NSCLC Non-small cell lung cancer, TGTC Testicular germ cell tumor, HCC Hepatocellular carcinoma, CC Cervical cancer; OS Overall survival, DFS Disease-free survival, NR Not report, M Multivariate analysis, C Curves, IHC Immunohistochemistry, HR Hazard ratio; ^a the intensity (intensity score: 0, negative; 1, weak; 2, moderate; 3, strong) and percentage of the total cell population (proportion score:0 < 10%; 10% ≤ 1 ≤ 33%; 34% ≤ 2 ≤ 66%; 67% ≤ 3 ≤ 100%); ^b staining intensity was divided into three steps (scores 0, 1, and 2) in the infiltrated region of each case. When score 0 was defined as negative and score 1 and score 2 were positive; ^cTRIM44 staining was evaluated based on intensity scores (0, no staining; 1, weak staining; 2, moderate staining; and 3±, strong staining) and percentage scores (0, 0%; 1 ≤ 25%; 2, > 25%- ≤ 50%; 3, 50% > − ≤ 75%; 4, > 75%)

ISSN: 1471-2407