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Table 2 Treatment planning (PTVWB-A = Planning target volume of the whole brain in arm A, PTVWB-B = Planning target volume of the whole brain in arm B, PTVmet = Planning target volume of metastases)

From: Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

Radiation treatment planning

PTVWB- A or -B

PTVmet

Major deviations

Prescribed total dose to PTV

30 Gy

51Gy

(brain stem metastasis and resection cavity: 42Gy)

< or > 30Gy for PTVWB-A or -B

< or > 51Gy for PTVmet (brain stem metastasis and resection cavity: < or > 42Gy)

Prescribed dose per fraction in PTV

2.5 Gy

4.25Gy

(brain stem metastasis and resection cavity: 3.5Gy)

< or > 2.5Gy for PTVWB-A or -B

< or > 4.25Gy for PTVmet

(brain stem metastasis and resection cavity: 3.5Gy)

Number of fractions per day

1

1

>  1

Treatment duration

12 days

5 days/week

12 days

5 days/week

< or > 12 days

< 4 or > 5 days/week