Table 1 Univariate analyses of prognostic factors for OS of stage III gastric cancer
Variables | 5-year OS (%) | No. of patients | Univariate | ||
|---|---|---|---|---|---|
n | % | HR (95% CI) | p value | ||
Total | 48.7 | 225 | 100 | ||
Age (years) | |||||
≤ 68 | 54.0 | 117 | 52.0 | 1 | |
> 68 | 42.8 | 108 | 48.0 | 1.643 (1.164–2.319) | 0.005 |
Sex | |||||
Male | 47.3 | 147 | 65.3 | 1 | |
Female | 51.2 | 78 | 34.7 | 1.188 (0.823–1.715) | 0.357 |
BMI (kg/m2) | |||||
Low (≤ 21.9) | 46.7 | 114 | 50.7 | 1 | |
High (> 21.9) | 50.6 | 111 | 49.3 | 0.950 (0.674–1.339) | 0.771 |
Performance status | |||||
0 | 52.1 | 167 | 74.2 | 1 | |
1–3 | 39.1 | 58 | 25.8 | 1.606 (1.109–2.325) | 0.012 |
Location | |||||
Upper/Middle/Lower | 50.7 | 209 | 92.9 | 1 | |
Whole | 20.6 | 16 | 7.1 | 1.334 (1.092–1.630) | 0.005 |
Macroscopic type | |||||
Type 0/1/2 | 56.9 | 61 | 27.1 | 1 | |
Type 3/4/5 | 45.6 | 164 | 72.9 | 1.145 (0.774–1.693) | 0.497 |
Operative procedure | |||||
Distal gastrectomy | 59.7 | 117 | 52.0 | 1 | |
Total gastrectomy | 36.9 | 108 | 48.0 | 1.835 (1.295–2.600) | 0.001 |
Lymph node dissection | |||||
D1 | 49.8 | 32 | 14.2 | 1 | |
D2 | 48.6 | 193 | 85.8 | 0.911 (0.553–1.500) | 0.713 |
Histology | |||||
Differentiated | 54.0 | 97 | 43.1 | 1 | |
Undifferentiated | 44.4 | 128 | 56.9 | 1.198 (0.846–1.697) | 0.308 |
Lymphatic invasion | |||||
Absent | 57.9 | 19 | 8.4 | 1 | |
Present | 47.8 | 206 | 91.6 | 1.174 (0.633–2.177) | 0.611 |
Venous invasion | |||||
Absent | 50.3 | 156 | 69.3 | 1 | |
Present | 44.8 | 69 | 30.7 | 1.193 (0.830–1.716) | 0.340 |
TNM sub-stage | |||||
IIIA | 62.2 | 80 | 35.6 | 1 | 0.011 |
IIIB | 45.4 | 72 | 32.0 | 1.579 (1.030–2.420) | 0.036 |
IIIC | 36.2 | 73 | 32.4 | 1.908 (1.242–2.931) | 0.003 |
Tumor size (mm) | |||||
≤ 60 | 55.9 | 115 | 51.1 | 1 | |
> 60 | 40.9 | 110 | 48.9 | 1.534 (1.086–2.166) | 0.015 |
Adjuvant chemotherapy | |||||
Absent | 40.1 | 41 | 18.2 | 1 | |
Present | 50.6 | 184 | 81.8 | 0.575 (0.382–0.865) | 0.008 |
CAR | |||||
Low (≤ 0.47) | 50.6 | 211 | 93.8 | 1 | |
High (> 0.47) | 21.4 | 14 | 6.2 | 2.844 (1.561–5.181) | 0.001 |
NLR | |||||
Low (≤ 1.90) | 58.0 | 99 | 44.0 | 1 | |
High (> 1.90) | 41.2 | 126 | 56.0 | 1.400 (0.986–1.988) | 0.060 |
PLR | |||||
Low (≤ 172) | 53.2 | 141 | 62.7 | 1 | |
High (> 172) | 40.9 | 84 | 37.3 | 1.376 (0.970–1.953) | 0.074 |
PNI | |||||
Low (≤ 45.6) | 39.0 | 90 | 40.0 | 1 | |
High (> 45.6) | 54.9 | 135 | 60.0 | 0.730 (0.517–1.031) | 0.074 |
GPS | |||||
0 | 51.1 | 171 | 76.0 | 1 | |
1/2 | 41.1 | 54 | 24.0 | 1.463 (0.992–2.156) | 0.055 |
PI | |||||
0 | 50.1 | 205 | 91.1 | 1 | |
1/2 | 35.0 | 20 | 8.9 | 1.592 (0.914–2.773) | 0.101 |