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Table 3 Genes with copy number alterations which are well known to be associated with cancer development and/or progression

From: The molecular pathogenesis of Trichilemmal carcinoma

Case

Chr

Start

End

Gene

Genetic alteration

 

2

Chr10

89,624,156

89,725,266

PTEN

Del

TC was reported in patients with Cowden syndrome, which is caused by germline PTEN deletion [6].

PTEN mutation is found in glioblastoma, endometrial carcinoma, lymphoma, thyroid, breast, prostate carcinoma, melanoma [12].

3

Chr20

39,657,593

39,752,015

TOP1

Amp

TOP1 amplification was reported in advanced and poor prognostic tumors in melanoma [13].

  1. Chr Chromosome, Del Deletion, Amp Amplification, TC Trichilemmal carcinoma