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Fig. 7 | BMC Cancer

Fig. 7

From: R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers

Fig. 7

R269C-ER decreases TGFβ expression in pancreatic cancer. a A string analysis of VASN gene is depicted. b MCF-7 and COLO-357 cells were seeded in phenol red depleted medium with charcoal stripped serum. Cells then were transfected with either WT-ER or R269C-ER in triplicates and treated with vehicle control or E2 (10nM) for 24 h. Total RNA was extracted and expression of TGFβ1 was assessed. Each graph represents ± SD. *, P < 0.05, **, P < 0.01. Representative experiment is shown

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