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Table 2 Correlation between postoperative pathology and clinicopathological features

From: Factors predictive of invasive ductal carcinoma in cases preoperatively diagnosed as ductal carcinoma in situ

Parameters

Postoperative pathology

p value

DCIS only

(n = 70)

Invasive ductal carcinoma

(n = 48)

Age at operation (years old)

  ≤ 60

50 (71.4%)

33 (68.8%)

 

  > 60

20 (28.6%)

15 (31.3%)

0.754

Symptoms

 Asymptomatic

30 (42.9%)

12 (25.0%)

 

 Symptomatic

40 (57.1%)

36 (75.0%)

0.044

Palpability

 Impalpabe

24 (34.3%)

9 (18.8%)

 

 Palpable

46 (65.7%)

39 (81.3%)

0.065

Tumor size (mm)

  ≤ 20.0

48 (68.6%)

23 (47.9%)

 

  > 20.0

22 (31.4%)

25 (52.1%)

0.024

Biopsy device

 Core needle biopsy

32 (45.7%)

35 (72.9%)

 

 Vacuum-assisted biopsy

38 (54.3%)

13 (27.1%)

0.003

Estrogen receptor

 Negative

9 (12.9%)

13 (27.1%)

 

 Positive

61 (87.1%)

35 (72.9%)

0.051

Progesterone receptor

 Negative

18 (25.7%)

19 (39.6%)

 

 Positive

52 (74.3%)

29 (60.4%)

0.111

HER2

  ≤ 2

63 (90.0%)

38 (79.2%)

 

 3

7 (10.0%)

10 (20.8%)

0.100

Ki67

  ≤ 14%

60 (85.7%)

38 (79.2%)

 

  > 14%

10 (14.3%)

10 (20.8%)

0.352

Grade of DCIS

 Low, intermediate

63 (90.0%)

35 (72.9%)

 

 High

7 (10.0%)

13 (27.1%)

0.015

Comedonecrosis

 Absence

37 (52.9%)

17 (35.4%)

 

Presence

33 (47.1%)

31 (64.6%)

0.061

Intraductal calcification

 Absence

62 (88.6%)

37 (77.1%)

 

 Presence

8 (11.4%)

11 (22.9%)

0.098

Lymphoid infiltrate

 Negative, mild

56 (80.0%)

27 (56.3%)

 

 Moderate, severe

14 (20.0%)

21 (43.8%)

0.006

Platelets–lymphocyte ratio

 Low

50 (71.4%)

24 (50.0%)

 

 High

20 (28.6%)

24 (50.0%)

0.018

LDH

  ≤ ULN

63 (90.0%)

42 (87.5%)

 

  > ULN

7 (10.0%)

6 (12.5%)

0.670

CEA

  ≤ ULN

66 (94.3%)

45 (93.8%)

 

  > ULN

4 (5.7%)

4 (5.7%)

0.904

CA15–3

  ≤ ULN

69 (98.6%)

46 (95.8%)

 

  > ULN

1 (1.4%)

2 (4.2%)

0.353

  1. DCIS Ductal carcinoma in situ, HER2 Human epidermal growth factor receptor 2, LDH Lactate dehydrogenease, ULN Upper limit of normal, CEA Carcinoembryonic antigen