Fig. 2

Adaptive immune and Immune checkpoint biomarker expression impact on five-year patient survival. Dichotomisation was based on the cut-off calculated using a ROC curve. Cases falling into the high group are represented by the red line with the blue line representing low expression for a CD3, b CD4, c CD8, d CD45RO, e ICOS and f PD-1. g IDO-1, was dichotomised based on expression of the biomarker in tumour, stroma or both, while h PD-L1, was grouped based on clinically established cut-off points (< 1%, 1–49 and > 50%). For IDO-1 and PD-L1 the dichotomisation is represented in the key for each biomarkers respectively. Log-rank p values are shown for each graph