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Table 4 Risk factors associated with postoperative disease free survival and overall survival identified by multivariate Cox regression analysis

From: Perioperative blood transfusion has distinct postsurgical oncologic impact on patients with different stage of hepatocellular carcinoma

Variables

OS

DFS

HR (95% CI)

p-value

HR (95% CI)

p-value

The entire cohort (n = 1255)

 Age, yr, ≤50 vs > 50

  

0.800 (0.688–0.931)

0.004

 Cirrhosis, yes vs no

  

1.328 (1.117–1.578)

0.001

 ALBI grade, 2 + 3 vs 1

1.225 (1.005–1.494)

0.044

  

 NLR, > 2.3 vs ≤ 2.3

1.080 (1.041–1.121)

< 0.001

1.034 (1.002–1.068)

0.040

 Tumor size, cm, > 5 vs ≤ 5

1.437 (1.077–1.916)

0.014

1.311 (1.073–1.602)

0.008

 Tumor no., multiple vs solitary

1.489 (1.206–1.838)

< 0.001

1.583 (1.343–1.866)

< 0.001

 Macro-VTT, yes vs no

1.662 (1.288–2.143)

< 0.001

1.377 (1.126–1.685)

0.002

 MVI, yes vs no

1.581 (1.262–1.980)

< 0.001

1.541 (1.298–1.829)

< 0.001

 AFP, μg/L, > 400 vs ≤ 400

1.412 (1.154–1.726)

0.001

1.267 (1.086–1.477)

0.003

 PBT, yes vs no

1.623 (1.312–2.008)

< 0.001

1.365 (1.158–1.608)

< 0.001

BCLC 0-A subgroup (n = 804)

 Age, yr, ≤50 vs > 50

  

0.986 (0.977–0.994)

0.001

 Cirrhosis, yes vs no

  

1.325 (1.053–1.668)

0.016

 ALBI grade, 2 + 3 vs 1

1.434 (1.094–1.879)

0.009

  

 NLR, > 2.3 vs ≤ 2.3

1.105 (1.056–1.157)

< 0.001

1.054 (1.010–1.099)

0.016

 MVI, yes vs no

1.643 (1.217–2.220)

0.001

1.578 (1.252–1.988)

< 0.001

 AFP, μg/L, > 400 vs ≤ 400

1.832 (1.390–2.413)

< 0.001

1.445 (1.167–1.789)

0.001

 PBT, yes vs no

1.756 (1.302–2.368)

< 0.001

1.607 (1.272–2.031)

< 0.001

BCLC B-C subgroup (n = 451)

 Age, yr, ≤50 vs > 50

  

0.989 (0.980–0.999)

0.025

 Tumor size, cm, > 5 vs ≤ 5

  

1.826 (1.151–2.897)

0.011

 Tumor no., multiple vs solitary

1.546 (1.129–2.116)

0.007

  

 PLR, > 118.9 vs ≤ 118.9

1.002 (1.000–1.003)

0.013

  

 MVI, yes vs no

1.492 (1.059–2.102)

0.022

1.568 (1.253–1.961)

< 0.001

 Macro-VTT, yes vs no

2.033 (1.411–2.929)

< 0.001

1.367 (1.067–1.752)

0.011

 Cirrhosis, yes vs no

  

1.408 (1.083–1.830)

0.014

 PBT, yes vs no

1.257 (0.929–1.700)

0.139

1.203 (0.950–1.525)

0.126

  1. Abbreviation: OS overall survival, DFS disease free survival, HR hazard ratio, 95% CI 95% confident interval, ABLI grade albumin to bilirubin grade, NLR neutrophil to lymphocyte ratio, Macro-VTT macroscopic venous tumor thrombus, MVI microscopic vascular invasion, AFP alpha fetoprotein, PBT perioperative blood transfusion, PLR platelet to lymphocyte ratio