Table 1 Baseline characteristics of patients with PBT and those without PBT in different HCC stage subset in the entire cohort (n = 1255)
Variable | BCLC 0-A (n = 804) | BCLC B-C (n = 451) | ||||
|---|---|---|---|---|---|---|
PBT n = 171) | Non-PBT (n = 633) | P-value | PBT (n = 176) | Non-PBT (n = 275) | P-value | |
Demographic factors | ||||||
 Age, yr | 52.9 ± 12.5 | 50.9 ± 12.1 | 0.062 | 49.9 ± 12.2 | 49.1 ± 12.5 | 0.544 |
Sex, n (%) | ||||||
 Male | 139 (81.3) | 557 (88.0) | 0.220 | 157 (89.2) | 249 (90.5) | 0.644 |
 Female | 32 (18.7) | 76 (12.0) |  | 19 (10.8) | 26 (9.5) |  |
HBsAg, n (%) | ||||||
 Positive | 143 (83.6) | 545 (86.1) | 0.415 | 148 (84.1) | 228 (82.9) | 0.743 |
 Negative | 28 (16.4) | 88 (13.9) |  | 28 (15.9) | 47 (17.1) |  |
Cirrhosis, n (%) | ||||||
 Yes | 123 (71.9) | 427 (67.5) | 0.265 | 133 (75.6) | 198 (72) | 0.404 |
 No | 48 (28.1) | 206 (32.5) |  | 43 (24.4) | 77 (28) |  |
Hemoglobin, g/L | 129.7 ± 22.8 | 141.6 ± 17.5 | < 0.001 | 131.2 ± 23.1 | 140.3 ± 19.9 | 0.000 |
Platelet count, × 109 /L | 185.0 ± 64.5 | 201.3 ± 92.9 | 0.008 | 215.4 ± 113.3 | 207.1 ± 71.3 | 0.338 |
Prothrombin time, s | 13.0 ± 1.6 | 12.7 ± 0.9 | 0.001 | 13.1 ± 1.1 | 12.7 ± 1.3 | 0.001 |
ALT, U/L, median (range) | 39 (6565) | 33 (71428) | 0.024 | 42.5(8237) | 38.0(6522) | 0.189 |
ALBI grade, n (%) | ||||||
 Grade 1 | 84 (49.1) | 399 (63.0) | < 0.001 | 76 (43.2) | 160 (58.2) | 0.001 |
 Grade 2 | 84 (49.1) | 232 (36.7) |  | 99 (56.3) | 115 (41.8) |  |
 Grade 3 | 3 (1.8) | 2 (0.3) |  | 1 (0.5) | 0 |  |
Inflammatory factors | ||||||
 NLR, median (range) | 2.4 (0.5,13.0) | 1.9 (0.3,24.9) | < 0.001 | 2.5 (0.9,24.4) | 2.3 (0.6,18.3) | 0.013 |
 PLR, median (range) | 121.1 (21.61432.1) | 96.9 (19.4414.0) | < 0.001 | 133.9 (19.8751.0) | 119.6 (20.6314.6) | < 0.001 |
 APRI, median (range) | 0.6 (0.1,12.2) | 0.5 (0.1,21.1) | 0.038 | 0.6 (0.1,3.8) | 0.5 (0.1,5.7) | 0.079 |
Tumor characteristics | ||||||
 AFP, ug/L | ||||||
   ≥ 400 | 99 (42.1) | 214 (33.8) | 0.044 | 88 (50) | 149 (54.2) | 0.387 |
   < 400 | 72 (57.9) | 419 (66.2) |  | 88 (50) | 126 (45.8) |  |
  Tumor size, cm | 9.2 ± 6.1 | 6.2 ± 3.1 | < 0.001 | 10.7 ± 3.92 | 8.9 ± 3.5 | < 0.001 |
Tumor number, n (%) | ||||||
 Solitary | 167 (97.7) | 596 (94.2) | 0.049 | 59 (33.5) | 87 (31.6) | 0.975 |
 2 | 4 (2.3) | 29 (4.6) |  | 59 (33.5) | 102 (37.1) |  |
 3 | 0 (0) | 8 (1.2) |  | 18 (10.2) | 25 (9.1) |  |
 4 | 0 (0) | 0 (0) |  | 40 (22.8) | 61 (22.2) |  |
Tumor capsule, n (%) | ||||||
 Complete | 137 (80.1) | 574 (90.7) | < 0.001 | 107 (60.8) | 187 (68) | 0.118 |
 Incomplete | 34 (19.9) | 59 (9.3) |  | 69 (39.2) | 88 (32) |  |
Differentiation, n (%) | ||||||
 I+ II | 115 (67.3) | 465 (73.5) | 0.108 | 119 (67.6) | 193 (70.2) | 0.566 |
 III, IV | 56 (32.7) | 168 (26.5) |  | 57 (32.4) | 82 (29.8) |  |
MVI, n (%) | ||||||
 Yes | 50 (29.2) | 123 (19.4) | 0.006 | 79 (44.9) | 105 (38.2) | 0.158 |
 No | 121 (70.8) | 510 (80.6) |  | 97 (55.1) | 170 (61.8) |  |
PVTT, n (%) | ||||||
 Yes | 0 | 0 |  | 100 (56.8) | 116 (42.2) | 0.002 |
 No | 171 (100) | 633 (100) |  | 76 (43.2) | 159 (57.8) |  |
HVTT, n (%) | Â | Â | Â | Â | Â | 0.000 |
 Yes | 0 | 0 |  | 21 (11.9) | 7 (2.5) |  |
 No | 171 (100) | 633 (100) |  | 155 (88.1) | 268 (97.5) |  |
Surgical factors | ||||||
 Extent of resection, n (%) | ||||||
  Major | 64 (37.4) | 194 (30.6) | 0.092 | 126 (71.6) | 180 (65.5) | 0.174 |
  Minor | 107 (62.6) | 439 (69.4) |  | 50 (28.4) | 95 (34.5) |  |
Type of resection, n (%) | ||||||
 Anatomical | 62 (36.3) | 203 (32.1) | 0.302 | 97 (55.1) | 150 (54.5) | 0.906 |
  Nonanatomical | 109 (63.7) | 430 (67.9) |  | 79 (44.9) | 125 (45.5) |  |
Resection margin | ||||||
  ≤ 1 cm | 32 (18.7) | 58 (9.2) | < 0.001 | 56 (31.8) | 122 (44.4) | 0.008 |
  > 1 cm | 139 (81.3) | 575 (90.8) |  | 120 (68.2) | 153 (55.6) |  |
Pringle maneuver, n (%) | ||||||
 Yes | 111 (64.9) | 380 (60.0) | 0.245 | 114 (64.8) | 169 (61.4) | 0.477 |
 No | 60 (35.1) | 253 (40.0) |  | 62 (35.2) | 106 (38.6) |  |
 Blood loss, ml, median (range) | 1484.7 (200,12,000) | 200 (50,3000) | < 0.001 | 1000 (200,10,500) | 300 (30,2500) | < 0.001 |
Clavien-Dindo grade | ||||||
 I | 4 (2.3) | 9 (1.4) | 0.045 | 3 (1.7) | 8 (2.9) | 0.950 |
 II | 1 (0.6) | 9 (1.4) |  | 2 (1.1) | 4 (1.5) |  |
 III | 15 (8.8) | 31 (4.9) |  | 10 (5.7) | 18 (6.5) |  |
 IV | 2 (1.2) | 3 (0.5) |  | 3 (1.7) | 2 (0.7) |  |