Table 2 Correlations between the median expression levels of CYP19A1 mRNA and histopathologic features according to relapse
From: CYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse
Variables | Relapse (n = 61) | P values | Nonrelapsed (n =85) | |||
|---|---|---|---|---|---|---|
Low | High | Low | High | P values | ||
n (%) | n (%) | n (%) | n (%) | |||
Age | ||||||
≤50 years | 13 (21.3) | 12 (19.7) | 0.877 | 19 (22.4) | 16 (18.8) | 0.568 |
> 51 years | 18 (29.5) | 18 (29.5) | 24 (28.2) | 26 (30.6) | ||
Tobacco use | ||||||
Yes | 13 (21.3) | 10 (16.4) | 0.488 | 18 (21.2) | 14 (16.5) | 0.327 |
No | 18 (29.5) | 20 (32,8) | 24 (28.2) | 29 (34.1) | ||
Menopausal status | ||||||
Premenopausal | 12 (19.7) | 14 (23.0) | 0.529 | 20 (23.5) | 17 (20.0) | 0.574 |
Postmenopausal | 19 (31.1) | 16 (26.2) | 23 (27.1) | 25 (29.4) | ||
Tumor Grade | ||||||
G1 | 0 (0.0) | 4 (6.6) | 0.109 | 3 (3.5) | 7 (8.2) | 0.395 |
G2 | 26 (42.6) | 22 (36.1) | 30 (35.3) | 29 (34.1) | ||
G3 | 5 (8.2) | 4 (6.6) | 9 (10.6) | 7 (8.2) | ||
N Classification | ||||||
N0-N1 | 27 (44.3) | 24 (39.3) | 0.454 | 36 (42.4) | 40 (47.1) | 0.273 |
N2-N3 | 4 (6.6) | 6 (9.8) | 6 (7.1) | 3 (3.5) | ||
Tumor stage | ||||||
I | 3 (4.9) | 3 (4.9) | 0.216 | 4 (4.7) | 9 (10.6) | 0.247 |
II | 19 (31.1) | 12 (19.7) | 21 (24.7) | 22 (25.9) | ||
III | 9 (14.8) | 15 (24.6) | 17 (20.0) | 12 (14.1) | ||
Molecular subtype | ||||||
Luminal A | 1 (1.6) | 2 (3.3) | 0.4455 | 4 (4.7) | 8 (9.4) | 0.182 |
Luminal B | 17 (27.9) | 18 (29.5) | 19 (22.4) | 22 (25.9) | ||
Her2 overexpression | 4 (6.6) | 6 (9.8) | 8 (9.4) | 5 (5.9) | ||
Triple-negative | 9 (14.8) | 4 (6.6) | 10 (11.8) | 8 (9.4) | ||
Estrogen receptors | ||||||
Positive | 22 (36.1) | 25 (41.0) | 0.250 | 30 (35.3) | 18 (21.2) | 0.532 |
Negative | 9 (14.8) | 5 (8.2) | 12 (14.1) | 15 (17.6) | ||
Progesterone receptors | ||||||
Positive Negative | 22 (36.1) 9 (14.8) | 19 (31.1) 11 (18.0) | 0.525 | 27 (31.8) 15 (17.6) | 29 (34.1) 14 (16.5) | 0.759 |
HER2 | ||||||
Positive Negative | 5 (8.2) 26 (42.6) | 12 (19.7) 18 (29.5) | < 0.0376 | 9 (10.6) 33 (38.8) | 9 (10.6) 34 (40.0) | 0.955 |
Histological type | ||||||
Ductal | 23 (37.7) | 23 (37.7) | 0.584 | 26 (30.6) | 32 (37.6) | 0.154 |
Lobular | 3 (4.9) | 1 (1.6) | 1 (1.2) | 3 (3.5) | ||
Other | 5 (8.2) | 6 (9.8) | 15 (17.6) | 8 (9.4) | ||
Recurrence type | ||||||
Locoregional | 0 (0.0) | 24 (39.3) | < 0.0001 | – | – | – |
Distant metastasis | 19 (31.1) | 18 (29.5) | – | – | ||