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Table 1 Correlations between the levels of CYP19A1 mRNA and histopathologic features in women with breast cancer

From: CYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse

Variables
Median age, 54 y (range, 34–82 y)
N (%)CYP19A1 Expressionp value
Low (%)High (%)
Age
 ≤50 years60 (41.1)31 (21.2)29 (19.9)0.73
 > 51 years86 (58.9)42 (28.8)44 (30.1) 
Tobacco use
 Yes55 (37.7)30 (20.5)25 (17.1)0.39
 No91 (62.3)43 (29.5)48 (32.9) 
Menopausal status
 Premenopausal63 (43.2)31 (21.2)32 (21.9)0.86
 Postmenopausal83 (56.8)42 (28.8)41 (28.1) 
Tumor Grade
 G114 (9.6)3 (2.1)11 (7.5)0.07
 G2107 (73.3)57 (39.0)50 (34.2) 
 G325 (17.1)13 (8.9)12 (8.2) 
N Classification
 N0-N1127 (87.0)62 (42.5)65 (44.5)0.46
 N2-N319 (13.0)11 (7.5)8 (5.5) 
Tumor stage
 I19 (13.0)7 (4.8)12 (8.2)0.40
 II74 (50.7)40 (27.4)34 (23.3) 
 III53 (36.3)26 (17.8)27 (18.5) 
Molecular subtype
 Luminal A16 (11.0)6 (4.1)10 (6.8)0.06
 Luminal B68 (45.2)36 (24.7)32 (21.9) 
 Her2 overexpression23 (15.8)12 (8.2)11 (7.5) 
 Triple-negative31 (21.2)19 (13.0)12 (8.2) 
 Hybrid Luminal8 (6.8)8 (5.5)0 (0.0) 
Estrogen receptors
 Positive Negative105 (71.9) 41 (28.1)52 (35.6) 21 (14.4)53 (36.3) 20 (13.7)0.85
Progesterone receptors
 Positive Negative97 (66.4) 49 (33.6)49 (33.6) 24 (16.4)48 (32.9) 25 (17.1)0.86
HER2
 Positive Negative35 (24.0) 111 (76.0)14 (9.6) 59 (40.4)21 (14.4) 52 (35.6)0.17
Histological type
 Ductal104 (71.2)50 (34.2)54 (37.0)0.73
 Lobular8 (5.5)4 (2.7)4 (2.7) 
 Other34 (23.3)19 (13.0)15 (10.3) 
Recurrence
 Yes61(41.8)32 (21.9)29 (19.9)0.61
 No85 (58.2)41(28.1)44 (30.1)