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Table 1 Associations from the IVW analysis that met at least the suggestive P value threshold. OR, CI and P value are from the IVW analysis. Results from the three sensitivity analyses (MR Egger, WME and MBE) are given in brief and take three values: “agree”, P value meets at least 0.05 and direction and magnitude of effect agrees with the IVW results; “disagree”, P value meets at least 0.05 and direction or magnitude of effect does not agree with the IVW results; “uncertain”, when the P value does not meet significance. Heterogeneity results are from the MR Egger intercept: high values of heterogeneity indicates potential pleiotropy. The instrument for telomere length did not consist of enough SNPs to conduct this analysis. Full results are given in detail in Additional file Table 4

From: Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study

Risk Factor

Subtype

OR

95% CI

P Value

MR Egger

WME

MBE

Heterogeneity (P value)

Telomere length

Non-GBM

4.05

1.72 to 9.56

1.38 × 10−3

Uncertain

Agree

Agree

NA

Alcohol consumption

GBM

8.37

1.69 to 41.54

9.36 × 10−3

Uncertain

Agree

Uncertain

0.43 (8.08 × 10−1)

Obesity (childhood extreme)

All glioma

1.11

1.02 to 1.21

1.63 × 10−2

Uncertain

Uncertain

Uncertain

5.19 (2.68 × 10−1)

Obesity (childhood extreme)

GBM

1.12

1.02 to 1.22

2.07 × 10−2

Uncertain

Uncertain

Uncertain

2.56 (6.34 × 10−1)

Telomere length

All glioma

4.09

1.13 to 14.86

3.24 × 10−2

Uncertain

Agree

Uncertain

NA

LDLc

Non-GBM

0.79

0.63 to 0.99

3.99 × 10−2

Uncertain

Uncertain

Uncertain

76.71 (5.20 × 10−1)

Alcohol consumption

All glioma

4.42

1.07 to 18.30

4.05 × 10−2

Uncertain

Agree

Uncertain

0.05 (9.75 × 10−1)

Allergic disease

GBM

1.29

1.01 to 1.67

4.76 × 10−2

Uncertain

Uncertain

Uncertain

185.58 (1.86 × 10−9)

Triglycerides

Non-GBM

0.77

0.59 to 1.00

4.86 × 10−2

Agree

Uncertain

Uncertain

77.49 (2.52 × 10−1)