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Table 3 Prognostic factors for progression-free survival with ovarian cancer selected by Cox’s uni- and multivariate analysis

From: Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer

VariablesUnivariate analysisMultivariate analysis
Hazard ratio (95%CI)PHazard ratio (95%CI)pHazard ratio (95%CI)p
Age (≥55)2.830 (1.043–7.682)0.041*1.045 (0.234–4.666)0.9540.781 (0.163–3.731)0.757
FIGO stage (III-IV)13.605 (3.157–58.631)< 0.001*7.299 (1.492–35.721)0.014*9.094 (1.723–48.010)0.009*
Histopathologic type (High-grade serous carcinoma)3.032 (1.268–7.249)0.013*1.885 (0.505–7.031)0.3451.937 (0.523–7.171)0.322
Completeness of surgical reduction (Suboptimal)8.007 (3.239–19.795)< 0.001*    
Treatment response (non-responders)16.067 (5.362–48.143)< 0.001*    
Tumor progression (platinum-resistant)38.183 (10.233–142.469)< 0.001*    
CA125 (≥399.3)2.730 (1.161–6.421)0.021*1.176 (0.413–3.350)0.7620.686 (0.222–2.114)0.511
Drp1 (≥10.5)11.338 (1.521–84.495)0.018*4.568 (0.551–37.879)0.159  
phospho-Drp1Ser637 (≥7.0)4.632 (1.912–11.220)0.001*  3.151 (1.039–9.561)0.043*
CaMKI (≥10.5)2.864 (1.161–7.065)0.022*1.809 (0.690–4.744)0.2282.740 (0.997–7.532)0.051
  1. * p < 0.05