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Table 3 Prognostic factors for progression-free survival with ovarian cancer selected by Cox’s uni- and multivariate analysis

From: Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer

Variables

Univariate analysis

Multivariate analysis

Hazard ratio (95%CI)

P

Hazard ratio (95%CI)

p

Hazard ratio (95%CI)

p

Age (≥55)

2.830 (1.043–7.682)

0.041*

1.045 (0.234–4.666)

0.954

0.781 (0.163–3.731)

0.757

FIGO stage (III-IV)

13.605 (3.157–58.631)

< 0.001*

7.299 (1.492–35.721)

0.014*

9.094 (1.723–48.010)

0.009*

Histopathologic type (High-grade serous carcinoma)

3.032 (1.268–7.249)

0.013*

1.885 (0.505–7.031)

0.345

1.937 (0.523–7.171)

0.322

Completeness of surgical reduction (Suboptimal)

8.007 (3.239–19.795)

< 0.001*

    

Treatment response (non-responders)

16.067 (5.362–48.143)

< 0.001*

    

Tumor progression (platinum-resistant)

38.183 (10.233–142.469)

< 0.001*

    

CA125 (≥399.3)

2.730 (1.161–6.421)

0.021*

1.176 (0.413–3.350)

0.762

0.686 (0.222–2.114)

0.511

Drp1 (≥10.5)

11.338 (1.521–84.495)

0.018*

4.568 (0.551–37.879)

0.159

  

phospho-Drp1Ser637 (≥7.0)

4.632 (1.912–11.220)

0.001*

  

3.151 (1.039–9.561)

0.043*

CaMKI (≥10.5)

2.864 (1.161–7.065)

0.022*

1.809 (0.690–4.744)

0.228

2.740 (0.997–7.532)

0.051

  1. * p < 0.05